GPR17
GPR17 Gene Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Predicted to act upstream of or within negative regulation of inflammatory response to antigenic stimulus. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GPR17 |
| Official Name | G protein-coupled receptor 17 [Source:HGNC Symbol;Acc:HGNC:4471] |
| Ensembl ID | ENSG00000144230 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 17 |
| Synonyms | AI853548,G protein-coupled receptor 17 |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- chemokine receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- receptor binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the GPR17 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- BTAF1
- NCAPG
- XPO5
- ZW10
- TONSL
- FOXO1
- COG8
- IPO11
- TBC1D15
- XPO7
disease
- neoplasia
- idiopathic pulmonary fibrosis
regulated by
- TLR7
- FOXO1
- PTEN
- TP53
- cisplatin
- oligodendrocytes
- UDP-D-glucose
- uracil nucleotide derivative
- RB1
- cysteinyl-leukotriene
regulates
- cyclic AMP
- CREB
- CASP3
- reactive oxygen species
- FOS
- KLF9
- XAF1
- MBP
- PKA
- RAPGEF3
role in cell
- proliferation
- expression in
- phosphorylation in
- growth
- apoptosis
- cell viability
- differentiation
- accumulation
- cisplatin sensitivity
- cell survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the GPR17 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of inflammatory response to antigenic stimulus
- oligodendrocyte differentiation
- positive regulation of Rho protein signal transduction
- G-protein coupled receptor signaling pathway
- chemokine-mediated signaling pathway
- phospholipase C-activating G-protein coupled receptor signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- G-protein coupled receptor activity
- receptor serine/threonine kinase binding
- chemokine receptor activity