CXCL14
CXCL14 Gene Summary
This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014]
Details
| Type | Protein Coding |
| Official Symbol | CXCL14 |
| Official Name | C-X-C motif chemokine ligand 14 [Source:HGNC Symbol;Acc:HGNC:10640] |
| Ensembl ID | ENSG00000145824 |
| Bio databases IDs | |
| Aliases | C-X-C motif chemokine ligand 14, breast and kidney |
| Synonyms | 1110031L23Rik,1200006I23Rik,BMAC,bolekine,BRAK,C-X-C motif chemokine ligand 14,KEC,KS1,MIP-2g,MIP2gamma,Mip2 γ,NJAC,SCYB14 |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta strand or sheet
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- alpha helix
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the CXCL14 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- F2R
- CXCL17
- CCL11
- CXCL11
- RPRD1B
- CCL21
- CCL13
- XCL1
- ZBTB1
- CXCL2
disease
- cancer
- non-small cell lung cancer
- hyperglycemia
- metastasis
- hypertrophic scarring
- Duchenne muscular dystrophy
- angiomatosis
- benign neoplasia
- squamous cell cancer of the oral cavity
- rheumatoid arthritis
regulated by
- diethylstilbestrol
- IL1B
- SMAD4
- EGF
- dexamethasone
- LGALS1
- EGFR
- lipopolysaccharide
- KRAS
- cephaloridine
regulates
- RAP1
- VIM
- 2-deoxyglucose
- SNAI1
- cholesterol
- RELA
- reactive oxygen species
- NFkB (complex)
- NOS1
- IFNG
role in cell
- activation in
- expression in
- production in
- phosphorylation in
- migration
- differentiation
- proliferation
- depolarization
- binding
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CXCL14 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- chemotaxis
- signal transduction
- cell-cell signaling
- cell chemotaxis
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- Golgi apparatus
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- chemokine activity