GNA12
GNA12 Gene Summary
Predicted to enable D5 dopamine receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in regulation of TOR signaling and regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GNA12 |
| Official Name | G protein subunit alpha 12 [Source:HGNC Symbol;Acc:HGNC:4380] |
| Ensembl ID | ENSG00000146535 |
| Bio databases IDs | |
| Aliases | G protein subunit alpha 12 |
| Synonyms | alpha subunit of the G12 family of HETEROTRIMERIC GS,FLJ21929,Galpha12,gep,G protein subunit alpha 12,G protein subunit α 12,G protein α 12,guanine nucleotide binding protein, alpha 12,guanine nucleotide binding protein, α 12,G α 12,HG1M1,NNX3,RMP,α subunit of the G12 family of HETEROTRIMERIC GS |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G protein alpha subunit
- mitochondrial presequence
- protein phosphatase binding
- small monomeric GTPase
- G-protein-coupled receptor binding
- protein phosphatase regulator
- GTPase
- enzyme
- protein binding
- GTPase domain
- G-protein alpha subunit
- phosphatase activator
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the GNA12 gene plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- AMPK Signaling
- Androgen Signaling
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cardiac β-adrenergic Signaling
- CCR3 Signaling in Eosinophils
- CCR5 Signaling in Macrophages
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Endothelin-1 Signaling
- Ephrin B Signaling
- Ephrin Receptor Signaling
- ERK5 Signaling
- fMLP Signaling in Neutrophils
- G Beta Gamma Signaling
- Gα12/13 Signaling
- Gαq Signaling
- IL-1 Signaling
- IL-8 Signaling
- Molecular Mechanisms of Cancer
- Relaxin Signaling
- RHOA Signaling
- Sperm Motility
- Thrombin Signaling
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- PRKCD
- PRKCB
- ARHGEF11
- PPP5C
- PPP2R1A
- ARHGEF1
- LPAR1
- HSP90AA1
- TJP1
- BTK
disease
- neoplasia
- cancer
- epithelial cancer
- colorectal cancer
- breast cancer
- esophageal cancer
- BCL2 translocation positive follicular lymphoma
- follicular non-Hodgkin disease
- chronic obstructive pulmonary disease
- major depression
regulated by
- tretinoin
- S1PR5
- GNB2
- GNB1
- FFAR2
- TSHR
- ARHGEF12
- dinoprost
- SHH
- MAPT
regulates
- SRC
- EGFR
- CXCL8
- ERK
- MAPK
- AKT1
- CTNNB1
- GSK3
- FOS
- Ca2+
role in cell
- apoptosis
- activation in
- serine phosphorylation in
- expression in
- proliferation
- growth
- transmembrane potential
- quantity
- migration
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Cytoplasm
- cellular membrane
- Mitochondria
- lateral plasma membrane
- neurites
- brush border
- cellular protrusions
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the GNA12 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of cell shape
- G-protein coupled receptor signaling pathway
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- response to xenobiotic stimulus
- blood coagulation
- Rho protein signal transduction
- regulation of blood pressure
- embryonic digit morphogenesis
- positive regulation of phosphoprotein phosphatase activity
- in utero embryonic development
- cell differentiation
- regulation of proteasomal ubiquitin-dependent protein catabolic process
- regulation of fibroblast migration
- regulation of TOR signaling cascade
CELLULAR COMPONENT
Where in the cell the gene product is active
- lateral plasma membrane
- brush border membrane
- heterotrimeric G-protein complex
- focal adhesion
- cytoplasm
- neuronal cell body
- neuron projection
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- GTP binding
- protein binding
- metal ion binding
- GTPase activity
- small monomeric GTPase activity
- G-protein beta/gamma-subunit complex binding
- protein phosphatase 2A binding
- D5 dopamine receptor binding
- protein phosphatase regulator activity