ITGB1
ITGB1 Gene Summary
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ITGB1 |
| Official Name | integrin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6153] |
| Ensembl ID | ENSG00000150093 |
| Bio databases IDs | |
| Aliases | integrin subunit beta 1 |
| Synonyms | 4633401G24RIK,beta1-Integrin,CD29,CD29 antigen,FNRB,Gm9863,GPIIA,integrin beta 1 (fibronectin receptor beta),integrin subunit beta 1,integrin subunit β 1,Integrin β 1,integrin β 1 (fibronectin receptor β),Integrin β 1 receptor,LOC102556297,MDF2,MSK12,VLAB,VLA-BETA,VLA-β,β1-Integrin,β(1)-integrins |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MIDAS motif
- Integrin beta chain VWA domain
- Integrin plexin domain
- cell adhesion molecule binding
- Integrin beta tail domain
- Integrin beta cytoplasmic domain
- NPXY motif
- cytoplasmic domain
- C-X3-C chemokine binding
- actin binding
- vWFA
- intracellular domain
- tail domain
- plexin/semaphorin/integrin domain
- transmembrane receptor
- coreceptor
- extracellular domain
- beta propeller
- protein kinase binding
- signaling receptor activity
- protease binding
- actinin binding
- ectodomain
- calcium ion binding
- Pkc binding domain
- protein domain specific binding
- protein binding
- receptor binding
- magnesium ion binding
- Integrin beta subunits (N-terminal portion of extracellular region)
- fibronectin binding
- binding protein
- kinase binding
- laminin binding
- transmembrane/cytoplasmic domain
- integrin binding
- transmembrane domain
- collagen binding
- cytosolic tail domain
- protein heterodimerization
- Integrin beta epidermal growth factor like domain 1
- specificity-determining loop
Pathways
Biological processes and signaling networks where the ITGB1 gene plays a role, providing insight into its function and relevance in health or disease.
- Actin Nucleation by ARP-WASP Complex
- Agranulocyte Adhesion and Diapedesis
- Agrin Interactions at Neuromuscular Junction
- Caveolar-mediated Endocytosis Signaling
- CDK5 Signaling
- Clathrin-mediated Endocytosis Signaling
- Ephrin Receptor Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Granulocyte Adhesion and Diapedesis
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- Macropinocytosis Signaling
- NF-κB Activation by Viruses
- PAK Signaling
- Paxillin Signaling
- Rac Signaling
- Reelin Signaling in Neurons
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Role of Tissue Factor in Cancer
- Semaphorin Signaling in Neurons
- Sertoli Cell-Sertoli Cell Junction Signaling
- TREM1 Signaling
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- MADCAM1
- XPO1
- EGFR
- NT5E
- CD47
- ABL1
- FLNA
- ITGA4
- MMP9
- ITGA5
disease
- neoplasia
- metastasis
- epithelial cancer
- fibrosis
- hypertension
- hepatocellular carcinoma
- liver cancer
- laser induced choroidal neovascularization
- ovalbumin-induced asthma
- experimentally-induced adenomyosis
regulated by
- STAT3
- ARID1A
- CD3 (complex)
- MAP2K7
- TNF
- PDGFR
- PDGF-BB
- nitroprusside
- RASGRP2
- palmitic acid
regulates
- JUN
- IL1
- NFkB (complex)
- PRKCA
- reactive oxygen species
- ITGA6
- MYC
- collagen
- THBS1
- FOXO3
role in cell
- proliferation
- formation
- phosphorylation in
- apoptosis
- expression in
- transformation
- number
- binding in
- growth
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- soluble fraction
- membrane fraction
- insoluble fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- apical ectoplasmic specialization
- membrane nanotubes
- glutaminergic synapse
- endoplasmic reticulum mitochondria contact site
- ruffle
- actin-rich protrusion
- Cajal band
- extracellular vesicles
- Cytoplasm
- invadopodia
- cell-substratum contacts
- cell-matrix contacts
- cell surface
- cell borders
- cell periphery
- intracellular space
- apical compartment
- basal compartment
- perinuclear region
- membrane surface
- cellular membrane
- focal complexes
- focal adhesions
- Nucleus
- endosomes
- vesicles
- Endoplasmic Reticulum
- costameres
- intercellular junctions
- hemidesmosomes
- cell-cell contacts
- granules
- basal cell surfaces
- lateral cell surfaces
- apical cell surfaces
- basolateral cell surfaces
- membrane ruffles
- plasma membrane extracellular face
- apical membrane
- postsynaptic membrane
- synaptic membrane
- basolateral membrane
- basal membrane
- lateral plasma membrane
- endosomal membrane
- acrosome
- dendritic spines
- myelin sheath outer loop
- synaptic vesicles
- neuromuscular junctions
- growth cone
- neurites
- dendritic trees
- synaptosomes
- synapse
- abaxonal membranes
- glial cell projections
- sarcolemma
- early endosomes
- late endosomes
- cytoplasmic vesicles
- microsomal membrane
- membrane rafts
- cellular protrusions
- filopodia
- cell membrane leading edge
- filopodial tip
- perikaryon
- axons
- dendrites
- postsynaptic density
- excitatory synapses
- exosomes
- cell-cell adherens junctions
- basement membrane
- lamellipodia
- phagocytic cups
- detergent-soluble fraction
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ITGB1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- cell projection organization
- myoblast differentiation
- transforming growth factor beta receptor signaling pathway
- cell migration involved in sprouting angiogenesis
- visual learning
- stress fiber assembly
- positive regulation of angiogenesis
- positive regulation of GTPase activity
- neuroblast proliferation
- in utero embryonic development
- regulation of cell cycle
- wound healing, spreading of epidermal cells
- cardiac muscle cell differentiation
- maintenance of blood-brain barrier
- positive regulation of wound healing
- B cell differentiation
- sarcomere organization
- positive regulation of neuroblast proliferation
- cardiac cell fate specification
- formation of radial glial scaffolds
- germ cell migration
- cellular defense response
- mesodermal cell differentiation
- cell-substrate adhesion
- receptor internalization
- cellular response to low-density lipoprotein particle stimulus
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
- viral entry into host cell
- negative regulation of Rho protein signal transduction
- negative regulation of vasoconstriction
- negative regulation of neuron differentiation
- positive regulation of fibroblast growth factor receptor signaling pathway
- cell adhesion
- homophilic cell adhesion
- leukocyte cell-cell adhesion
- dendrite morphogenesis
- positive regulation of vascular endothelial growth factor signaling pathway
- integrin-mediated signaling pathway
- negative regulation of anoikis
- G1/S transition of mitotic cell cycle
- regulation of collagen catabolic process
- basement membrane organization
- cell-cell adhesion mediated by integrin
- cell migration
- cell-matrix adhesion
- calcium-independent cell-matrix adhesion
- myoblast fusion
- cardiac muscle cell myoblast differentiation
- myoblast cell fate specification
- muscle organ development
- establishment of mitotic spindle orientation
- positive regulation of glutamate uptake involved in transmission of nerve impulse
- CD40 signaling pathway
- cell adhesion mediated by integrin
- axon extension
- positive regulation of apoptotic process
- extracellular matrix organization
- phagocytosis
- lamellipodium assembly
- heterotypic cell-cell adhesion
- leukocyte tethering or rolling
- positive regulation of fibroblast migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- cleavage furrow
- external side of plasma membrane
- synapse
- integrin complex
- extracellular vesicular exosome
- focal adhesion
- sarcolemma
- dendritic spine
- alpha2-beta1 integrin complex
- ruffle
- ruffle membrane
- alpha1-beta1 integrin complex
- neuromuscular junction
- alpha4-beta1 integrin complex
- alpha3-beta1 integrin complex
- lamellipodium
- alpha10-beta1 integrin complex
- alphav-beta1 integrin complex
- alpha11-beta1 integrin complex
- receptor complex
- synaptic membrane
- plasma membrane
- cell surface
- perinuclear region of cytoplasm
- melanosome
- cytoplasm
- membrane raft
- membrane
- alpha7-beta1 integrin complex
- intercalated disc
- filopodium
- recycling endosome
- alpha6-beta1 integrin complex
- endosome membrane
- alpha5-beta1 integrin complex
- myelin sheath abaxonal region
- alpha9-beta1 integrin complex
- alpha8-beta1 integrin complex
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein kinase binding
- coreceptor activity
- cell adhesion molecule binding
- protease binding
- integrin binding
- laminin binding
- magnesium ion binding
- protein binding
- actin binding
- protein heterodimerization activity
- cadherin binding
- calcium ion binding
- C-X3-C chemokine binding
- fibronectin binding
- viral receptor activity