CXCL13
CXCL13 Gene Summary
B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]
Details
| Type | Protein Coding |
| Official Symbol | CXCL13 |
| Official Name | C-X-C motif chemokine ligand 13 [Source:HGNC Symbol;Acc:HGNC:10639] |
| Ensembl ID | ENSG00000156234 |
| Bio databases IDs | |
| Aliases | C-X-C motif chemokine ligand 13, B-cell chemoattractant |
| Synonyms | 4631412M08RIK,ANGIE,ANGIE2,BCA-1,BLC,BLR1L,CXC CHEMOKINE,C-X-C motif chemokine ligand 13,SCYB13 |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- fibroblast growth factor binding
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- CXCR3 chemokine receptor binding
- receptor agonist activity
- cytokine
- heparin binding
- CXCR chemokine receptor binding
Pathways
Biological processes and signaling networks where the CXCL13 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- FN1
- ACKR4
- COL4
- CXCR3
- CXCR5
- STAT3
- NFKB2
- hvCkbp
- PF4V1
- G4R
disease
- metastasis
- endometriosis
- lung cancer
- squamous cell cancer of the oral cavity
- Sjögren syndrome
- dextran sodium sulfate-induced colitis
- rheumatoid arthritis
- immune thrombocytopenia
- early missed abortion
- systemic lupus erythematosus
regulated by
- TNF
- lipopolysaccharide
- tetradecanoylphorbol acetate
- MIAT
- SOD1
- SKAP2
- Bay 11-7082
- pro-inflammatory cytokine
- G6PD
- ZC3H12D
regulates
- Ca2+
- AKT
- ERK1/2
- IL10
- CXCR5
- VCAM1
- ICAM1
- MADCAM1
- Integrin alpha 4 beta 1
- Integrin alpha L beta 2
role in cell
- expression in
- activation in
- phosphorylation in
- quantity
- binding
- adhesion
- migration
- ubiquitination in
- tyrosine phosphorylation in
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CXCL13 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- cell-cell signaling
- regulation of angiogenesis
- cell surface receptor signaling pathway
- defense response to bacterium
- elevation of cytosolic calcium ion concentration
- chronic inflammatory response
- germinal center formation
- inflammatory response
- immune response
- regulation of humoral immune response
- cellular response to lipopolysaccharide
- chemokine-mediated signaling pathway
- lymphocyte chemotaxis across high endothelial venule
- positive regulation of T cell chemotaxis
- endothelial cell chemotaxis to fibroblast growth factor
- neutrophil chemotaxis
- negative regulation of endothelial cell chemotaxis to fibroblast growth factor
- positive regulation of integrin activation
- positive regulation of cell-cell adhesion mediated by integrin
- B cell chemotaxis
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- CCR10 chemokine receptor binding
- CXCR5 chemokine receptor binding
- CXCR chemokine receptor binding
- receptor agonist activity
- heparin binding
- fibroblast growth factor binding
- CXCR3 chemokine receptor binding
- chemokine activity