CXCL16
CXCL16 Gene Summary
Enables chemokine activity. Involved in several processes, including positive regulation of cell growth; response to interferon-gamma; and response to tumor necrosis factor. Located in extracellular space. Biomarker of COVID-19 and systemic scleroderma. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CXCL16 |
| Official Name | C-X-C motif chemokine ligand 16 [Source:HGNC Symbol;Acc:HGNC:16642] |
| Ensembl ID | ENSG00000161921 |
| Bio databases IDs | |
| Aliases | C-X-C motif chemokine ligand 16, CXC chemokine ligand 16 |
| Synonyms | 0910001K24Rik,AV290116,b2b498Clo,CX3CL16,CXCL16v1,CXCL16v2,CXCLG16,C-X-C motif chemokine ligand 16,SR-PSOX,Zmynd15 |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- scavenger receptor
- chemokine
- CXCL16 N-terminal chemokine domain
- chemokine receptor binding
- chemokine domain
- low-density lipoprotein receptor
- cytokine
Pathways
Biological processes and signaling networks where the CXCL16 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- SLC18A1
- APP
- KRTAP10-3
- FFAR2
- ATP12A
- ELAVL1
- HHATL
- AQP6
- BLK
- ACE2
disease
- lupus nephritis
- systemic lupus erythematosus
- COVID-19
- arthritis
- neoplasia
- diabetes mellitus
- insulin-dependent diabetes mellitus
- glioblastoma
- glioblastoma cancer
- pancreatic ductal adenocarcinoma
regulated by
- IL1B
- PP2/AG1879 tyrosine kinase inhibitor
- ionomycin
- MAPT
- EIF4E
- lipopolysaccharide
- IgE
- TNF
- IL33
- wortmannin
regulates
- Ca2+
- CCL2
- lipid
- CXCL8
- TNF
- NFKBIA
- IFNG
- cytokine
- Collagen(s)
- FN1
role in cell
- migration
- expression in
- activation in
- proliferation
- phosphorylation in
- growth
- production in
- response
- binding
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CXCL16 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- response to cytokine stimulus
- chemotaxis
- positive regulation of cell growth
- T cell chemotaxis
- signal transduction
- response to interferon-gamma
- receptor-mediated endocytosis
- response to tumor necrosis factor
- positive regulation of cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- membrane
- extracellular region
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- low-density lipoprotein receptor activity
- scavenger receptor activity
- chemokine activity