DIRAS3
DIRAS3 Gene Summary
This gene encodes a member of the ras superfamily. This gene is imprinted gene with monoallelic expression of the paternal allele which is associated with growth suppression. The encoded protein acts as a tumor suppressor whose function is abrogated in many ovarian and breast cancers. This protein may also play a role autophagy in certain cancer cells by regulating the autophagosome initiation complex. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | DIRAS3 |
| Official Name | DIRAS family GTPase 3 [Source:HGNC Symbol;Acc:HGNC:687] |
| Ensembl ID | ENSG00000162595 |
| Bio databases IDs | |
| Aliases | DIRAS family GTPase 3, GTP-binding protein Di-Ras3, distinct subgroup of the Ras family member 3 |
| Synonyms | ARHI,DIRAS family GTPase 3,NOEY2,RHOI |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- effector domain
- Ras subfamily of RAS small GTPases
- CAAX box
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the DIRAS3 gene plays a role, providing insight into its function and relevance in health or disease.
- Actin Nucleation by ARP-WASP Complex
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Glioblastoma Multiforme Signaling
- Glioma Invasiveness Signaling
- Gαq Signaling
- HMGB1 Signaling
- IL-8 Signaling
- ILK Signaling
- Integrin Signaling
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of Actin-based Motility by Rho
- RhoGDI Signaling
- Semaphorin Signaling in Neurons
- Serotonin Receptor Signaling
- Signaling by Rho Family GTPases
- Sphingosine-1-phosphate Signaling
- Tec Kinase Signaling
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- PTPN1
- NISCH
- XPR1
- ANK3
- VANGL2
- MDM2
- BASP1
- MPP1
- LSR
- WT1
disease
- non-insulin-dependent diabetes mellitus
- serous ovarian adenocarcinoma
- serous ovarian cancer
- prostatic carcinoma
- prostate cancer
- epithelial cancer
- atrial fibrillation
regulated by
- E2F1
- genistein
- trichostatin A
- decitabine
- E2F4
- PIK3CA
- calcitriol
- mir-221 (includes others)
- AHR
- mir-1305
regulates
- synthetic promoter
- progesterone
- PRL
- RHOA
- STAT3
- MT1L
- DNA promoter
- COL2A1
- F2
- TFPI2
role in cell
- apoptosis
- proliferation
- growth
- formation
- invasion by
- development
- colony formation by
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the DIRAS3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- small GTPase mediated signal transduction
- genetic imprinting
- regulation of cyclin-dependent protein kinase activity
CELLULAR COMPONENT
Where in the cell the gene product is active
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- GDP binding