CXCR1
CXCR1 Gene Summary
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CXCR1 |
| Official Name | C-X-C motif chemokine receptor 1 [Source:HGNC Symbol;Acc:HGNC:6026] |
| Ensembl ID | ENSG00000163464 |
| Bio databases IDs | |
| Aliases | C-X-C motif chemokine receptor 1 |
| Synonyms | C-C,C-C-CKR-1,CD128,CD181,CDw128a,CHEMOKINE CXC1 receptor,CKR-1,CMKAR1,CR1,C-X-C motif chemokine receptor 1,IL18R1,IL8R1,IL8RA,IL8RBA |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- intracellular loop
- Cholecystokinin A receptor, N-terminal
- interleukin-8 receptor
- allosteric site
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- chemokine receptor
- transmembrane domain
- intracellular domain
- extracellular loop
- interleukin-8 binding
- 7 transmembrane receptor (rhodopsin family)
Pathways
Biological processes and signaling networks where the CXCR1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CXCR2
- CXCL8
- GNAI2
- CLDND1
- PPBP
- ADAM10
- CCR5
- SB-265610
- 2'-((4'-trifluoromethanesulfonyloxy)phenyl)-N-methanesulfonylpropionamide
- SX-682
disease
- rheumatoid arthritis
- pneumonia
- organismal death
- diffuse large B-cell lymphoma
- multiple organ failure
- pruritus
- lung adenocarcinoma
- lung adenocarcinoma formation
- diabetes mellitus
- COVID-19
regulated by
- TNF
- TP53
- dexamethasone
- lipopolysaccharide
- E. coli K235 lipopolysaccharide
- TGFB1
- CXCL1
- hymecromone
- genistein
- SU6656
regulates
- ERK1/2
- MMP9
- ERK
- CXCL8
- PRKCE
- superoxide
- CCND1
- Ca2+
- GNAO1
- phosphatidylinositol
role in cell
- phosphorylation in
- proliferation
- production in
- killing
- expression in
- cell death
- migration
- formation
- formation in
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- secretory granule membrane
- apical membrane
- perinuclear space
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CXCR1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- immune response
- G-protein coupled receptor signaling pathway
- chemokine-mediated signaling pathway
- interleukin-8-mediated signaling pathway
- dendritic cell chemotaxis
- neutrophil chemotaxis
- cell surface receptor signaling pathway
- calcium-mediated signaling
- receptor internalization
- elevation of cytosolic calcium ion concentration
CELLULAR COMPONENT
Where in the cell the gene product is active
- secretory granule membrane
- external side of plasma membrane
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- C-C chemokine binding
- G-protein coupled receptor activity
- interleukin-8 binding
- protein binding
- C-C chemokine receptor activity
- interleukin-8 receptor activity
- chemokine receptor activity