PIP5KL1
PIP5KL1 Gene Summary
PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I PIPKs (see PIP5K1A; MIM 603275) and may play a role in localization of PIPK activity (Chang et al., 2004 [PubMed 14701839]).[supplied by OMIM, Jun 2009]
Details
| Type | Processed Transcript |
| Official Symbol | PIP5KL1 |
| Official Name | phosphatidylinositol-4-phosphate 5-kinase like 1 [Source:HGNC Symbol;Acc:HGNC:28711] |
| Ensembl ID | ENSG00000167103 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol-4-phosphate 5-kinase like 1 |
| Synonyms | phosphatidylinositol-4-phosphate 5-kinase-like 1,PIPKH |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
- Phosphatidylinositol-4-phosphate 5-Kinase
- protein binding
- 1-phosphatidylinositol-4-phosphate 5-kinase
Pathways
Biological processes and signaling networks where the PIP5KL1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ABCF3
- PIP5K1B
- HSPA9
- PIP5K1C
- LRP1
- PAX6
- PIP5K1A
- AGAP2
disease
regulated by
- USP37
- LRP1
- PIP5KL1
- PIP5K1A
- PIP5K1B
- PPP3R1
- CBS
- Bacillus anthracis Sterne strain 7702
- NDP
- ARID2
regulates
- PIP5KL1
- Egfp
- BTK
- phosphatidylinositol-3,4,5-triphosphate
role in cell
- apoptosis
- migration
- reorganization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytosol
- cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PIP5KL1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of mitochondrial membrane potential
- negative regulation of protein phosphorylation
- positive regulation of apoptotic process
- phosphatidylinositol phosphorylation
- negative regulation of cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- cytosol
- cell projection
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ATP binding
- 1-phosphatidylinositol-4-phosphate 5-kinase activity