CX3CR1
CX3CR1 Gene Summary
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Details
| Type | Protein Coding |
| Official Symbol | CX3CR1 |
| Official Name | C-X3-C motif chemokine receptor 1 [Source:HGNC Symbol;Acc:HGNC:2558] |
| Ensembl ID | ENSG00000168329 |
| Bio databases IDs | |
| Aliases | C-X3-C motif chemokine receptor 1 |
| Synonyms | CCRL1,CMKBLR1,CMKBRL1,CMKDR1,C-X3-C motif chemokine receptor 1,Fractalkine receptor,GPR13,GPRV28,mCX3CR1,RBS11,V28 |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- C-X3-C chemokine receptor
- Cholecystokinin A receptor, N-terminal
- chemokine receptor
- chemokine receptor binding
- C-X3-C chemokine binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- cytokine receptor
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the CX3CR1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CX3CL1
- NFATC1
- ITGA4
- ITGB3
- CCDC167
- g
- NFATC2
- HTT
disease
- infection
- migraines
- lupus nephritis
- rheumatoid arthritis
- COVID-19
- septic shock
- fibrosis
- neoplasia
- Parkinson disease
- Alzheimer disease
regulated by
- NR3C1
- lipopolysaccharide
- Cyp2c23
- cyclosporin A
- NRAS
- AHR
- losartan potassium
- SOD1
- PTEN
- NKX3-1
regulates
- NOS2
- TNF
- IL6
- ICAM1
- IL1B
- AMPK
- p38 MAPK
- HMOX1
- EGR1
- SLC2A2
role in cell
- expression in
- proliferation
- activation
- phosphorylation in
- damage
- survival
- migration
- quantity
- response
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- endosomal membrane
- neurites
- dendritic trees
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CX3CR1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of long-term synaptic potentiation
- negative regulation of interleukin-1 beta production
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- response to wounding
- microglial cell activation involved in immune response
- cell adhesion
- memory
- regulation of nitric oxide biosynthetic process
- positive regulation of angiogenesis
- cell chemotaxis
- chemotaxis
- immune response
- response to ischemia
- regulation of synaptic plasticity
- cellular response to tumor necrosis factor
- calcium-mediated signaling
- social behavior
- G-protein coupled receptor signaling pathway
- central nervous system maturation
- synapse maturation
- positive regulation of monocyte chemotaxis
- regulation of tumor necrosis factor production
- cell-cell signaling
- adaptive immune response
- positive regulation of neuroblast proliferation
- brain development
- phospholipase C-activating G-protein coupled receptor signaling pathway
- elevation of cytosolic calcium ion concentration
- cellular defense response
- cellular response to transforming growth factor beta stimulus
- homeostasis of number of cells in a free-living population
- cellular response to lipopolysaccharide
- innate immune response
- chemokine-mediated signaling pathway
- regulation of synaptic transmission
- positive regulation of neurogenesis
- leukocyte tethering or rolling
- leukocyte chemotaxis
- regulation of neurogenesis
- negative regulation of apoptotic signaling pathway
- positive regulation of protein kinase B signaling cascade
- negative regulation of cell migration
- autocrine signaling
CELLULAR COMPONENT
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- external side of plasma membrane
- neuronal cell body membrane
- neuron projection
- plasma membrane
- cell surface
MOLECULAR FUNCTION
What the gene product does at the molecular level
- C-C chemokine binding
- CX3C chemokine receptor binding
- G-protein coupled receptor activity
- G-protein coupled peptide receptor activity
- protein binding
- C-C chemokine receptor activity
- C-X3-C chemokine binding
- C-X3-C chemokine receptor activity
- chemokine receptor activity