CXCL10
CXCL10 Gene Summary
This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. This gene may also be a key regulator of the 'cytokine storm' immune response to SARS-CoV-2 infection. [provided by RefSeq, Sep 2020]
Details
| Type | Protein Coding |
| Official Symbol | CXCL10 |
| Official Name | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] |
| Ensembl ID | ENSG00000169245 |
| Bio databases IDs | |
| Aliases | C-X-C motif chemokine ligand 10 |
| Synonyms | C7,CRG-2,C-X-C motif chemokine ligand 10,gamma-IFN INDUCIBLE EARLY RESPONSE,gIP-10,IFI10,IFNG INDUCIBLE protein-10,INP10,Interferon-inducible protein-10,IP-10,mob-1,SCYB10,SMALL INDUCIBLE CYTOKINE SUBFAMILY B (Cys-X-Cys), member 10,γ-IFN INDUCIBLE EARLY RESPONSE |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- chemoattractant
- Small cytokines (intecrine/chemokine), interleukin-8 like
- furin cleavage consensus sequence
- CXCR3 chemokine receptor binding
- cAMP-dependent protein kinase regulator
- protein binding
- receptor binding
- cytokine
- heparin binding
Pathways
Biological processes and signaling networks where the CXCL10 gene plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Communication between Innate and Adaptive Immune Cells
- Granulocyte Adhesion and Diapedesis
- IL-17A Signaling in Gastric Cells
- Neuroinflammation Signaling Pathway
- Pathogenesis of Multiple Sclerosis
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of MAPK Signaling in the Pathogenesis of Influenza
- VDR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CCL26
- CCL28
- PPBP
- CXCR3
- CXCL12
- IRF5
- IGFBP7
- CXCL11
- heparin
- STAT1
disease
- neoplasia
- precursor B-cell acute lymphoblastic leukemia
- renal clear cell adenocarcinoma
- breast carcinoma
- epithelial cancer
- hepatocellular carcinoma
- systemic lupus erythematosus
- Alzheimer disease
- asthma
- rheumatoid arthritis
regulated by
- HIBCH
- TAC1
- MAP2K6
- E. coli
- TLR4
- myeloid dendritic cells
- peripheral blood natural killer cells
- IFNG
- SUMO3
- lipopolysaccharide
regulates
- MAPK1
- MEK
- RHOA
- PI3K (complex)
- ERK
- AKT
- reactive oxygen species
- JNK
- RELA
- Ca2+
role in cell
- expression in
- growth
- production in
- proliferation
- cell death
- phosphorylation in
- cell viability
- survival
- transmigration
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- exosporium
- coat layer
- Cytoplasm
- cell surface
- intracellular space
- plasma membrane extracellular face
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CXCL10 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- endothelial cell activation
- negative regulation of angiogenesis
- response to vitamin D
- positive chemotaxis
- positive regulation of cell proliferation
- positive regulation of transcription from RNA polymerase II promoter
- chemotaxis
- inflammatory response
- regulation of T cell chemotaxis
- cellular response to heat
- T cell chemotaxis
- response to auditory stimulus
- response to gamma radiation
- G-protein coupled receptor signaling pathway
- signal transduction
- positive regulation of monocyte chemotaxis
- cell-cell signaling
- blood circulation
- regulation of apoptotic process
- cell surface receptor signaling pathway
- positive regulation of release of sequestered calcium ion into cytosol
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- regulation of cell proliferation
- muscle organ development
- positive regulation of T cell migration
- cellular response to lipopolysaccharide
- negative regulation of myoblast differentiation
- chemokine-mediated signaling pathway
- neutrophil chemotaxis
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- external side of plasma membrane
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- CXCR chemokine receptor binding
- chemoattractant activity
- heparin binding
- CXCR3 chemokine receptor binding
- chemokine activity
- cAMP-dependent protein kinase regulator activity
- receptor binding