FPR1
FPR1 Gene Summary
This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]
Details
| Type | Protein Coding |
| Official Symbol | FPR1 |
| Official Name | formyl peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:3826] |
| Ensembl ID | ENSG00000171051 |
| Bio databases IDs | |
| Aliases | formyl peptide receptor 1 |
| Synonyms | Alxr,fMLF-R,FMLP,FORMYL PEPTIDE receptor,formyl peptide receptor 1,FPR,LXA4R |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- G-protein-coupled receptor binding
- N-formyl peptide receptor
- protein binding
- receptor binding
- seven-transmembrane G protein-coupled receptor superfamily
- phosphorylation site
- scavenger receptor binding
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- cytosolic tail domain
- loop domain
Pathways
Biological processes and signaling networks where the FPR1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- N-formyl-Met-Leu-Phe
- FPR2
- XPO5
- RAB18
- PRKDC
- ANXA1
- ATL3
- MSMO1
- MAPK13
- XPO1
disease
- diabetes mellitus
- peripheral arterial disease
- multiple sclerosis
- tumorigenesis
- lung cancer
- respiratory disorder
- systemic sclerosis
- chronic obstructive pulmonary disease
- ischemic stroke
- Crohn disease
regulated by
- lipopolysaccharide
- BHLHE40
- tetradecanoylphorbol acetate
- Mrgpra2a (includes others)
- Immunoglobulin
- methotrexate
- NQO1
- CSF2
- defensin
- E. coli B4 lipopolysaccharide
regulates
- reactive oxygen species
- cyclic AMP
- MAPK1
- AKT
- MAPK3
- Ca2+
- ERK1/2
- EGFR
- adenosine triphosphate
- GNAI2
role in cell
- activation in
- cellular infiltration by
- chemotaxis
- phagocytosis by
- production in
- quantity
- accumulation in
- growth
- maturation
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- soluble fraction
- membrane fraction
- Cytoplasm
- cell surface
- membrane surface
- cellular membrane
- secretory granule membrane
- granules
- tertiary granule membrane
- cytosol
- lysosome membrane
- chromosome
- secretory vesicles
- tertiary granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the FPR1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- chemotaxis
- inflammatory response
- G-protein coupled receptor signaling pathway
- nitric oxide mediated signal transduction
- signal transduction
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- phospholipase C-activating G-protein coupled receptor signaling pathway
- complement receptor mediated signaling pathway
- elevation of cytosolic calcium ion concentration
CELLULAR COMPONENT
Where in the cell the gene product is active
- secretory granule membrane
- cytoplasm
- membrane
- azurophil granule membrane
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- G-protein coupled receptor activity
- complement receptor activity
- G-protein coupled receptor binding
- protein binding
- N-formyl peptide receptor activity
- scavenger receptor binding
- RAGE receptor binding