GNB2
GNB2 Gene Summary
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GNB2 |
| Official Name | G protein subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:4398] |
| Ensembl ID | ENSG00000172354 |
| Bio databases IDs | |
| Aliases | G protein subunit beta 2, G protein, beta-2 subunit, guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 2, signal-transducing guanine nucleotide-binding regulatory protein beta subunit, transducin beta chain 2 |
| Synonyms | G protein subunit beta 2,G protein subunit β 2,G protein β 2,guanine nucleotide binding protein (G protein), beta 2,guanine nucleotide binding protein (G protein), β 2,HG2C1,SSS4,SSS4 NEDHYDF,Transducin Beta2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- WD40 repeats
- alpha helix
- WD domain, G-beta repeat
- enzyme binding
- GTPase
- WD40
- protein binding
- calcium channel regulator
Pathways
Biological processes and signaling networks where the GNB2 gene plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Androgen Signaling
- Antiproliferative Role of Somatostatin Receptor 2
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cardiac β-adrenergic Signaling
- CCR3 Signaling in Eosinophils
- CCR5 Signaling in Macrophages
- CXCR4 Signaling
- Endocannabinoid Developing Neuron Pathway
- Ephrin B Signaling
- fMLP Signaling in Neutrophils
- G Beta Gamma Signaling
- Glutamate Receptor Signaling
- Gαq Signaling
- Gαs Signaling
- IL-1 Signaling
- Molecular Mechanisms of Cancer
- P2Y Purinergic Receptor Signaling Pathway
- Phospholipase C Signaling
- Protein Kinase A Signaling
- RhoGDI Signaling
- Thrombin Signaling
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- HRAS
- EGFR
- RPL5
- ITGB1
- CCT3
- TARDBP
- SNRNP70
- PRKN
- XPO1
- GNG5
disease
- rheumatoid arthritis
- Parkinson disease
- neurodevelopmental disorder with hypotonia and dysmorphic facies
- sick sinus syndrome type 4
- essential thrombocythemia
- global developmental delay
regulated by
- AGT
- BRAF
- GNB1
- CLEC11A
- SYVN1
- RAC2
- ANXA7
- DDX3X
- AGN194204
- ADRA2
regulates
- AHR
- Ca2+
- IL1B
- Cxcl2
- ERK
- K+
- actin
- DGAT1
- NR4A1
- GNA12
role in cell
- activation in
- phosphorylation in
- apoptosis
- chemotaxis
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- myelin enriched fraction
- synaptic vesicle membrane
- Cytoplasm
- perinuclear region
- cellular membrane
- Nucleus
- Golgi Apparatus
- cytosol
- growth cone
- synapse
- photoreceptor inner segments
- membrane rafts
- perikaryon
- excitatory synapses
- exosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the GNB2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- heterotrimeric G-protein complex
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- membrane
- vesicle
- cytosol
- plasma membrane
- lysosomal membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- GTPase activity
- GTPase binding
- receptor signaling complex scaffold activity