GNG12

GNG12 Gene Summary

Enables PDZ domain binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

Details

Type
Protein Coding
Official Symbol
GNG12
Official Name
G protein subunit gamma 12 [Source:HGNC Symbol;Acc:HGNC:19663]
Ensembl ID
ENSG00000172380
Bio databases IDs NCBI: 55970 Ensembl: ENSG00000172380
Aliases G protein subunit gamma 12
Synonyms
2010305F15Rik,G protein subunit gamma 12,G protein subunit γ 12,G protein γ 12,guanine nucleotide binding protein (G protein), gamma 12,guanine nucleotide binding protein (G protein), γ 12,HG3A
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • GGL
  • enzyme
  • protein binding
  • phosphate binding
  • GGL domain
  • PDZ-domain binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • ESR2
  • GLP1R
  • PPP2CA
  • MEN1
  • IFITM3
  • ACTC1
  • MYH9
  • TBP
  • MOSPD2
  • IFITM1
disease
  • colorectal cancer
  • aortic valve calcification
regulated by
  • EGF
  • beta-estradiol
  • GNB2
  • mir-802
  • n-nitrosomethylbenzylamine
  • MASTL
  • ESR1
  • MCOLN1
  • NKX2-3
  • GNB1
regulates
  • PLCB2
  • FGD1/3
role in cell
  • activation in
  • migration
  • formation
  • cell rounding

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • pH resistant lipid raft fraction
  • detergent resistant lipid raft fraction
  • cellular membrane
  • Nucleus
  • actin filaments
  • synapse

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the GNG12 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • G-protein coupled receptor signaling pathway
  • signal transduction

CELLULAR COMPONENT

Where in the cell the gene product is active
  • extracellular vesicular exosome
  • heterotrimeric G-protein complex
  • plasma membrane

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • protein binding
  • G-protein beta-subunit binding
  • PDZ domain binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.