GNG5
GNG5 Gene Summary
G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]
Details
| Type | Processed Transcript |
| Official Symbol | GNG5 |
| Official Name | G protein subunit gamma 5 [Source:HGNC Symbol;Acc:HGNC:4408] |
| Ensembl ID | ENSG00000174021 |
| Bio databases IDs | |
| Aliases | G protein subunit gamma 5 |
| Synonyms | GNGT5,G protein subunit gamma 5,G protein subunit γ 5,G protein γ 5,G(y)5 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GGL
- protein binding
- GGL domain
- PDZ-domain binding
Pathways
Biological processes and signaling networks where the GNG5 gene plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Androgen Signaling
- Antiproliferative Role of Somatostatin Receptor 2
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cardiac β-adrenergic Signaling
- CCR3 Signaling in Eosinophils
- CCR5 Signaling in Macrophages
- CXCR4 Signaling
- Endocannabinoid Developing Neuron Pathway
- Ephrin B Signaling
- Ephrin Receptor Signaling
- fMLP Signaling in Neutrophils
- G Beta Gamma Signaling
- Glutamate Receptor Signaling
- Gαq Signaling
- IL-1 Signaling
- IL-8 Signaling
- Molecular Mechanisms of Cancer
- P2Y Purinergic Receptor Signaling Pathway
- Protein Kinase A Signaling
- Relaxin Signaling
- RhoGDI Signaling
- Sperm Motility
- Thrombin Signaling
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- GNB1
- GNB2
- GOLGA2
- H1-3
- TRAF1
- GNB4
- CD81
- RAB11A
- MAPT
- GNA11
disease
- failure of heart looping
- hypoplasia
- pervasive developmental disorder
- essential thrombocythemia
regulated by
- SOD1
- GNB2
- GNB1
- CEBPD
regulates
- GPCR
role in cell
- apoptosis
- proliferation
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the GNG5 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- signal transduction
- positive regulation of neural precursor cell proliferation
- positive regulation of secondary heart field cardioblast proliferation
CELLULAR COMPONENT
Where in the cell the gene product is active
- heterotrimeric G-protein complex
- extracellular vesicular exosome
- membrane
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- G-protein beta-subunit binding
- GTPase activity
- PDZ domain binding