CCR4
CCR4 Gene Summary
The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CCR4 |
| Official Name | C-C motif chemokine receptor 4 [Source:HGNC Symbol;Acc:HGNC:1605] |
| Ensembl ID | ENSG00000183813 |
| Bio databases IDs | |
| Aliases | C-C motif chemokine receptor 4 |
| Synonyms | C-C CKR-4,C-C motif chemokine receptor 4,CCR4 receptor,CD194,CHEMOKINE CC4 receptor,CHEMR1,ChemR13,CKR4,CMKBR4,HGCN:14099,K5-5,LESTR,nocturnin,Sdf1r |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- C-C chemokine receptor
- Cholecystokinin A receptor, N-terminal
- chemokine receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the CCR4 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CCL17
- NSUN2
- CLPTM1
- CCL5
- SLCO4A1
- ATP2A2
- BSG
- CCL22
- GATA3
- FLX475
disease
- neoplasia
- metastasis
- atopic dermatitis
- recurrent cutaneous T-cell lymphoma
- experimental autoimmune encephalomyelitis
- multiple sclerosis
- mycosis fungoides
- Sézary syndrome
- rheumatoid arthritis
- obesity
regulated by
- lipopolysaccharide
- Propionibacterium acnes
- IL10
- TCR (complex)
- TGFB1
- CCL22
- KDM6A
- GATA1
- PDGF-BB
- NEF
regulates
- ERK1/2
- AKT
- Ca2+
- PTK2
- TNF
- IFNG
- DGKA
- CSF2
- FOS
- cytokine
role in cell
- phosphorylation in
- growth
- quantity
- activation in
- migration
- mobilization in
- chemotaxis
- cellular infiltration by
- number
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CCR4 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- chemotaxis
- response to bacterium
- inflammatory response
- immune response
- chemokine-mediated signaling pathway
- homeostasis of number of cells
- positive regulation of positive chemotaxis
- tolerance induction
- calcium-mediated signaling
- cell chemotaxis
- elevation of cytosolic calcium ion concentration
CELLULAR COMPONENT
Where in the cell the gene product is active
- external side of plasma membrane
- neuronal cell body
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- C-C chemokine binding
- protein binding
- C-C chemokine receptor activity
- chemokine receptor activity