FNBP1
FNBP1 Gene Summary
The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FNBP1 |
| Official Name | formin binding protein 1 [Source:HGNC Symbol;Acc:HGNC:17069] |
| Ensembl ID | ENSG00000187239 |
| Bio databases IDs | |
| Aliases | formin binding protein 1 |
| Synonyms | 1110057E06RIK,2210010H06RIK,FBP1,FBP17,Formin binding,formin binding protein 1,LOC102555088,LOC108348147,RAPOSTLIN,RND2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fes/CIP4, and EFC/F-BAR homology domain
- enzyme
- protein binding
- inserted domain
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- HR1
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the FNBP1 gene plays a role, providing insight into its function and relevance in health or disease.
- Actin Nucleation by ARP-WASP Complex
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Glioblastoma Multiforme Signaling
- Glioma Invasiveness Signaling
- Gαq Signaling
- HMGB1 Signaling
- IL-8 Signaling
- ILK Signaling
- Integrin Signaling
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of Actin-based Motility by Rho
- RhoGDI Signaling
- Semaphorin Signaling in Neurons
- Serotonin Receptor Signaling
- Signaling by Rho Family GTPases
- Sphingosine-1-phosphate Signaling
- Tec Kinase Signaling
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- IQUB
- FGFR1
- TRIM67
- VIRMA
- HNRNPL
- EGFR
- RBPJ
- PTEN
- HSPA1A
- DAAM1
disease
- severe acute respiratory syndrome
- juvenile rheumatoid arthritis
regulated by
- TGFB1
- TNF
- TCR (complex)
- guanosine triphosphate
- ARNT2
- SIM1
- beta-estradiol
- CREBBP
- AGN194204
- L-methionine
regulates
- actin
- TF
- DNM2
role in cell
- formation
- density
- morphology
- invasiveness
- invagination
- mesenchymal motility
- branching
- reorganization
- amoeboid motility
- invagination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- Plasma Membrane
- cytosol
- interchromatin granule clusters
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the FNBP1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- signal transduction
- endocytosis
CELLULAR COMPONENT
Where in the cell the gene product is active
- cytoskeleton
- intracellular membrane-bounded organelle
- coated pit
- cell cortex
- cytoplasmic vesicle
- cytosol
- plasma membrane
- lysosome
MOLECULAR FUNCTION
What the gene product does at the molecular level
- identical protein binding
- protein binding
- lipid binding