PIK3R4
PIK3R4 Gene Summary
Predicted to enable protein serine/threonine kinase activity. Involved in positive regulation of phosphatidylinositol 3-kinase activity; receptor catabolic process; and regulation of cytokinesis. Located in late endosome and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PIK3R4 |
| Official Name | phosphoinositide-3-kinase regulatory subunit 4 [Source:HGNC Symbol;Acc:HGNC:8982] |
| Ensembl ID | ENSG00000196455 |
| Bio databases IDs | |
| Aliases | phosphoinositide-3-kinase regulatory subunit 4 |
| Synonyms | 2210010O15Rik,C730038E05Rik,D9Ertd418e,p150,phosphoinositide-3-kinase regulatory subunit 4,phosphoinositide-3-kinase, regulatory subunit 4,VPS15 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- HEAT repeat
- phosphatidylinositol 3-kinase
- kinase domain
- WD40 repeats
- Protein Kinases, catalytic domain
- WD domain, G-beta repeat
- WD40
- protein binding
Pathways
Biological processes and signaling networks where the PIK3R4 gene plays a role, providing insight into its function and relevance in health or disease.
- Apelin Cardiomyocyte Signaling Pathway
- Apelin Pancreas Signaling Pathway
- Clathrin-mediated Endocytosis Signaling
- CNTF Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- ErbB Signaling
- ErbB4 Signaling
- Glucocorticoid Receptor Signaling
- Growth Hormone Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-9 Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- Mouse Embryonic Stem Cell Pluripotency
- MSP-RON Signaling Pathway
- Neurotrophin/TRK Signaling
- NGF Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- p53 Signaling
- PDGF Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Th1 Pathway
- Th2 Pathway
- Thyroid Cancer Signaling
- UVA-Induced MAPK Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- PARD6A
- CETN2
- BAG6
- FLII
- APLNR
- FANCD2
- PFDN2
- ITPR1
- RAB9A
- PIK3C3
disease
- non-insulin-dependent diabetes mellitus
regulated by
- IL6
- NRBF2
- gentamicin
- metronidazole
- vancomycin
- kanamycin A
- colistin
- arsenic trioxide
- TP53
- guanosine triphosphate
regulates
- HAMP
- EEA1
- SGK3
- phosphatidylinositol-3,4,5-triphosphate
- phosphatidylinositol-3-phosphate
- phosphatidylinositol
- glycogen
- receptor
- RAB5
- PIK3R4
role in cell
- formation
- synthesis in
- autophagy by
- response by
- cytokinesis in
- replication in
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- microtubule cytoskeleton
- intracellular membrane-bounded organelle
- cilia
- perinuclear region
- basal bodies
- axonemes
- cytoplasmic bridges
- cytosol
- early endosomes
- late endosomes
- perinuclear vesicles
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PIK3R4 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- late endosome to vacuole transport
- phosphatidylinositol-3-phosphate biosynthetic process
- protein targeting to lysosome
- protein phosphorylation
- protein targeting to vacuole
- cellular response to glucose starvation
- protein kinase B signaling cascade
- receptor catabolic process
- early endosome to late endosome transport
- regulation of autophagy
- regulation of macroautophagy
- peroxisome degradation
- regulation of cytokinesis
- macroautophagy
CELLULAR COMPONENT
Where in the cell the gene product is active
- phosphatidylinositol 3-kinase complex II
- microtubule cytoskeleton
- phosphatidylinositol 3-kinase complex I
- phosphatidylinositol 3-kinase complex, class III
- late endosome
- autophagic vacuole
- axoneme
- nucleus-vacuole junction
- intracellular membrane-bounded organelle
- membrane
- cytosol
- phagocytic vesicle membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein kinase activity
- protein serine/threonine kinase activity