MYL6B
MYL6B Gene Summary
Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | MYL6B |
| Official Name | myosin light chain 6B [Source:HGNC Symbol;Acc:HGNC:29823] |
| Ensembl ID | ENSG00000196465 |
| Bio databases IDs | |
| Aliases | myosin light chain 6B, myosin light chain 1 slow a |
| Synonyms | 5730437E04Rik,LOC107987175,MLC1SA,myosin light chain 6B,myosin, light polypeptide 6B |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- EF-hand domain
- structural constituent of muscle
- EF-hand domain pair
- EFh
- protein binding
- motor protein
- EFh_PI-PLC
Pathways
Biological processes and signaling networks where the MYL6B gene plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Agranulocyte Adhesion and Diapedesis
- Apelin Cardiomyocyte Signaling Pathway
- Calcium Signaling
- Cardiac Hypertrophy Signaling
- Cdc42 Signaling
- Cellular Effects of Sildenafil (Viagra)
- CXCR4 Signaling
- Ephrin A Signaling
- Estrogen Receptor Signaling
- G-Protein Coupled Receptor Signaling
- Gα12/13 Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- ILK Signaling
- PAK Signaling
- Phagosome Formation
- Regulation of Actin-based Motility by Rho
- RhoA Signaling
- RhoGDI Signaling
- Signaling by Rho Family GTPases
- Thrombin Signaling
- Tight Junction Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ESR1
- KIF20A
- FANCD2
- TRIM67
- FARP1
- TNIP1
- HUWE1
- CUL3
- CDC123
- SOX2
disease
- severe acute respiratory syndrome
- rotator cuff injury
regulated by
- CRYBA1
- KDM5A
- D-alpha-hydroxyglutarate
- SIX1
- RB1
regulates
role in cell
- sliding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the MYL6B gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- muscle contraction
- skeletal muscle tissue development
- muscle filament sliding
CELLULAR COMPONENT
Where in the cell the gene product is active
- myosin complex
- extracellular vesicular exosome
- muscle myosin complex
- myosin II complex
- unconventional myosin complex
- cytosol
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- structural constituent of muscle
- calcium ion binding
- motor activity