C5AR1
C5AR1 Gene Summary
Enables G protein-coupled receptor activity and complement component C5a receptor activity. Involved in several processes, including complement component C5a signaling pathway; mRNA transcription by RNA polymerase II; and positive regulation of ERK1 and ERK2 cascade. Located in apical part of cell and basolateral plasma membrane. Biomarker of Alzheimer's disease; asthma; chronic obstructive pulmonary disease; rhinitis; and severe acute respiratory syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | C5AR1 |
| Official Name | complement C5a receptor 1 [Source:HGNC Symbol;Acc:HGNC:1338] |
| Ensembl ID | ENSG00000197405 |
| Bio databases IDs | |
| Aliases | complement C5a receptor 1 |
| Synonyms | C5AR,C5R1,CD88,complement C5a receptor 1,complement component 5a receptor 1,D7Msu1,LEUKOTRIENE C5 receptor |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- activation domain
- complement component C5 receptor
- intracellular loop
- Cholecystokinin A receptor, N-terminal
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- phosphorylation site
- cytoplasmic domain
- transmembrane domain
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- transmembrane receptor
Pathways
Biological processes and signaling networks where the C5AR1 gene plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Breast Cancer Regulation by Stathmin1
- Cellular Effects of Sildenafil (Viagra)
- Complement System
- CREB Signaling in Neurons
- FAK Signaling
- G-Protein Coupled Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- Phagosome Formation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ATP2B2
- C5
- ITPR2
- SLC30A5
- EVI5L
- NELFE
- GRK2
- CLN3
- Chips
- REEP4
disease
- cancer
- microscopic polyangiitis
- metastasis
- advanced cancer
- Devic syndrome
- reperfusion injury
- airway hyperresponsiveness
- neoplasia
- acute septic peritonitis
- peripheral arterial disease
regulated by
- lipopolysaccharide
- APOE
- TNF
- dexamethasone
- N-formyl-Met-Leu-Phe
- ERBB2
- C5
- NR5A2
- BLVRA
- progesterone
regulates
- Ca2+
- MAPK1
- TNF
- IL1B
- ERK1/2
- 1,4,5-IP3
- IL6
- MMP9
- MAPK3
- AKT
role in cell
- expression in
- production in
- migration
- accumulation in
- phosphorylation in
- apoptosis
- differentiation
- activation in
- proliferation
- permeability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endoplasmic reticulum/Golgi apparatus fractions
- plasma membrane fraction
- cell surface
- intracellular space
- apical compartment
- cellular membrane
- Endoplasmic Reticulum
- membrane compartment
- secretory granule membrane
- apical cell surfaces
- apical membrane
- basolateral membrane
- chromosome
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the C5AR1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- response to peptidoglycan
- signal transduction
- positive regulation of neutrophil chemotaxis
- phospholipase C-activating G-protein coupled receptor signaling pathway
- complement receptor mediated signaling pathway
- positive regulation of angiogenesis
- elevation of cytosolic calcium ion concentration
- astrocyte activation
- beta-amyloid clearance
- sensory perception of chemical stimulus
- microglial cell activation
- chemotaxis
- cellular defense response
- inflammatory response
- immune response
- cognition
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of macrophage chemotaxis
- neutrophil chemotaxis
- positive regulation of epithelial cell proliferation
- defense response to Gram-positive bacterium
- positive regulation vascular endothelial growth factor production
CELLULAR COMPONENT
Where in the cell the gene product is active
- secretory granule membrane
- apical part of cell
- basolateral plasma membrane
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- G-protein coupled receptor activity
- complement component C5a receptor activity