MYL4
MYL4 Gene Summary
Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | MYL4 |
| Official Name | myosin light chain 4 [Source:HGNC Symbol;Acc:HGNC:7585] |
| Ensembl ID | ENSG00000198336 |
| Bio databases IDs | |
| Aliases | myosin light chain 4, myosin, atrial/fetal muscle, light chain, atrial myosin light chain 1 |
| Synonyms | ALC1,AMLC,ELC,Elc1a,GT1,Malc,MLC1,MLC-1a,MLC1EMB,MLC2A,Myla,myosin light chain 4,myosin, light chain 4,myosin, light polypeptide 4,PRO1957 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- actin monomer binding
- EFh
Pathways
Biological processes and signaling networks where the MYL4 gene plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Agranulocyte Adhesion and Diapedesis
- Apelin Cardiomyocyte Signaling Pathway
- Calcium Signaling
- Cardiac Hypertrophy Signaling
- Cdc42 Signaling
- Cellular Effects of Sildenafil (Viagra)
- CXCR4 Signaling
- Ephrin A Signaling
- Estrogen Receptor Signaling
- G-Protein Coupled Receptor Signaling
- Gα12/13 Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- ILK Signaling
- PAK Signaling
- Phagosome Formation
- Regulation of Actin-based Motility by Rho
- RhoA Signaling
- RhoGDI Signaling
- Signaling by Rho Family GTPases
- Thrombin Signaling
- Tight Junction Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- MYOD1
- TCF3
- SRF
- NR2C2
- FN1
- MYOG
- CUL5
- CUL3
- F Actin
- MITF
disease
- familial atrial fibrillation type 18
- Duchenne muscular dystrophy
- familial atrial fibrillation
regulated by
- cyclosporin A
- TP53
- EPHB4
- BDNF
- H9c2 cells
- HTT
- MYOD1
- LMNA
- EDNRB
- DNMT3A
regulates
- CAMK4
- ATPase
- MYL4
- NFATC4
role in cell
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- sarcomere
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the MYL4 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of the force of heart contraction
- positive regulation of ATPase activity
- cardiac muscle contraction
CELLULAR COMPONENT
Where in the cell the gene product is active
- myosin II complex
- cytosol
- A band
MOLECULAR FUNCTION
What the gene product does at the molecular level
- actin filament binding
- calcium ion binding
- myosin II heavy chain binding
- actin monomer binding