ACKR1
ACKR1 Gene Summary
The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ACKR1 |
| Official Name | atypical chemokine receptor 1 (Duffy blood group) [Source:HGNC Symbol;Acc:HGNC:4035] |
| Ensembl ID | ENSG00000213088 |
| Bio databases IDs | |
| Aliases | atypical chemokine receptor 1 (Duffy blood group), atypical chemokine receptor 1, glycoprotein D |
| Synonyms | atypical chemokine receptor 1,atypical chemokine receptor 1 (Duffy blood group),CCBP1,CD234,Chemokine receptor,DARC,DARC/ACKR1,DFY,Duffy,ESTM35,FY,Fy glycoprotein,Glycoprotein D,GPD,GpFy,WBCQ1 |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- signaling receptor activity
- C-C chemokine binding
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the ACKR1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CCR5
- fimA6
- CCL11
- LMNA
- MTNR1B
- CCL17
- CXCL8
- CCL7
- CCL2
- CXCL1
disease
- head and neck squamous cell carcinoma
- angiomatosis
- androgenic alopecia
- diabetic nephropathy
- head and neck squamous cell cancer
- endometriosis
- hemangioma
- uterine leiomyoma
- leiomyomatosis
- infection by Plasmodium falciparum
regulated by
- HTT
- CERK
- ATN1
- IL1B
- TGFB1
- SMAD4
- lipopolysaccharide
- levodopa
- OSM
- HSP90AA1
regulates
- ERK1/2
- Ca2+
- TNFAIP3
- VCAM1
- CCL2
- CXCL8
- CITED2
- IFI16
- MYO5A
- SIK1
role in cell
- binding
- expression in
- formation
- formation in
- activation in
- migration
- recruitment
- entrance
- cellular infiltration by
- signaling by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- vesicles
- apical cell surfaces
- basolateral cell surfaces
- apical membrane
- caveolae
- basolateral membrane
- basal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ACKR1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- inflammatory response
- chemokine-mediated signaling pathway
- regulation of chemokine production
- defense response
CELLULAR COMPONENT
Where in the cell the gene product is active
- early endosome
- recycling endosome
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- C-C chemokine binding
- G-protein coupled receptor activity
- transmembrane signaling receptor activity
- signaling receptor activity