ITGA1
ITGA1 Gene Summary
This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ITGA1 |
| Official Name | integrin subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:6134] |
| Ensembl ID | ENSG00000213949 |
| Bio databases IDs | |
| Aliases | integrin subunit alpha 1, very late antigen-1 |
| Synonyms | alpha1 INTEGRIN,CD49A,E130012M19RIK,integrin alpha 1,integrin subunit alpha 1,integrin subunit α 1,Integrin α-1,VLA1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- von Willebrand factor (vWF) type A domain
- cell adhesion molecule binding
- protein phosphatase binding
- extracellular membrane-proximal domain
- von Willebrand factor type A domain
- inserted domain
- protein binding
- receptor binding
- alpha1 domain
- FG-GAP-like repeat
- Integrin alpha (beta-propellor repeats)
- Integrin alpha
- cytoplasmic domain
- vWFA
- transmembrane domain
- intracellular domain
- collagen binding
- VWFA-related Acidobacterial domain
- phosphatase activator
- cytosolic tail domain
- membrane-proximal domain
- FG-GAP repeat
Pathways
Biological processes and signaling networks where the ITGA1 gene plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Caveolar-mediated Endocytosis Signaling
- Cdc42 Signaling
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- HGF Signaling
- Integrin Signaling
- Molecular Mechanisms of Cancer
- Osteoarthritis Pathway
- PAK Signaling
- Paxillin Signaling
- PI3K/AKT Signaling
- PTEN Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- RhoGDI Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Signaling by Rho Family GTPases
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- Collagen type III
- ITGB1
- VIRMA
- SHARPIN
- collagen alpha1
- MYC
- COL1A1
- IQGAP3
- RAC1
- Collagen type VI
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- colitis
- plaque psoriasis
- metastasis
- hyperalbuminemia
- endometriosis
- coronary artery disease
- chronic obstructive pulmonary disease
- mesangiolysis
regulated by
- tretinoin
- NLRX1
- ID2
- ENTPD2
- TGFB1
- MYC
- rosiglitazone
- OXT
- Collagen type IV
- TYA-018
regulates
- TNF
- EGFR
- PPARG
- CD36
- insulin
- PTGS2
- IFNG
- Laminin1
- reactive oxygen species
- MAPK14
role in cell
- apoptosis
- production in
- quantity
- proliferation
- expression in
- activation in
- phosphorylation in
- formation
- adhesion
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cell surface
- cell borders
- basal compartment
- cellular membrane
- focal adhesions
- membrane ruffles
- plasma membrane extracellular face
- acrosome
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ITGA1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- cell-matrix adhesion
- negative regulation of cell proliferation
- neuron projection morphogenesis
- positive regulation of MAPK cascade
- vasodilation
- negative regulation of epidermal growth factor receptor signaling pathway
- positive regulation of neuron apoptotic process
- integrin-mediated signaling pathway
- cell adhesion mediated by integrin
- positive regulation of phosphoprotein phosphatase activity
- cellular extravasation
- neutrophil chemotaxis
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular vesicular exosome
- focal adhesion
- basal part of cell
- acrosomal vesicle
- membrane
- external side of plasma membrane
- alpha1-beta1 integrin complex
- perikaryon
- integrin complex
- plasma membrane
- cell surface
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- protein phosphatase binding
- collagen binding
- metal ion binding
- integrin binding