ITGB3
ITGB3 Gene Summary
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ITGB3 |
| Official Name | integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] |
| Ensembl ID | ENSG00000259207 |
| Bio databases IDs | |
| Aliases | integrin subunit beta 3, platelet glycoprotein IIIa, antigen CD61 |
| Synonyms | BDPLT16,BDPLT2,BDPLT24,beta 3,CD61,GP3A,GPIIIa,GT,GT2,HPA-4,INGRB3,integrin beta 3,integrin subunit beta 3,integrin subunit β 3,Integrin-β 3,β 3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MIDAS motif
- Integrin beta chain VWA domain
- Integrin plexin domain
- cell adhesion molecule binding
- insulin-like growth factor binding
- inserted domain
- identical protein binding
- head domain
- Integrin beta tail domain
- Integrin beta cytoplasmic domain
- NPXY motif
- ligand-induced binding site
- cytoplasmic domain
- beta-tail domain
- C-X3-C chemokine binding
- vWFA
- membrane-proximal domain
- plexin/semaphorin/integrin domain
- transmembrane receptor
- growth factor binding
- coreceptor
- extracellular domain
- protein disulfide-isomerase
- protease binding
- extracellular matrix binding
- protein kinase C binding
- platelet-derived growth factor receptor binding
- enzyme binding
- helical domain
- calpain cleavage site
- protein binding
- vascular endothelial growth factor receptor binding
- Integrin beta subunits (N-terminal portion of extracellular region)
- fibronectin binding
- EGF-like domain
- binding protein
- fibroblast growth factor binding
- ICY domain
- integrin binding
- transmembrane domain
- NXXY motif
- cytosolic tail domain
- tyrosine phosphorylation site
- Integrin beta epidermal growth factor like domain 1
- specificity-determining loop
Pathways
Biological processes and signaling networks where the ITGB3 gene plays a role, providing insight into its function and relevance in health or disease.
- Actin Nucleation by ARP-WASP Complex
- Caveolar-mediated Endocytosis Signaling
- Clathrin-mediated Endocytosis Signaling
- Ephrin Receptor Signaling
- Glioma Invasiveness Signaling
- GP6 Signaling Pathway
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- Integrin Signaling
- Macropinocytosis Signaling
- Molecular Mechanisms of Cancer
- NF-κB Activation by Viruses
- P2Y Purinergic Receptor Signaling Pathway
- PAK Signaling
- Paxillin Signaling
- PTEN Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of Tissue Factor in Cancer
- Sertoli Cell-Sertoli Cell Junction Signaling
- TR/RXR Activation
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- APP
- TLN2
- HSP90B1
- ITGAV
- ITGA2B
- MYH9
- COL4A3
- CCN2
- SPP1
- IGFBP2
disease
- bleeding
- neoplasia
- experimental autoimmune encephalomyelitis
- lung cancer
- plasma cell myeloma
- lung metastasis
- squamous cell lung cancer
- lung adenocarcinoma
- lung squamous cell carcinoma
- epithelial cancer
regulated by
- PRKG1
- let-7 (includes others)
- 2-deoxyglucose
- Ca2+
- MEOX2
- macrophages
- homocysteine
- beta-estradiol
- tretinoin
- IL3
regulates
- TP53
- TNF
- IL1B
- D-glucose
- glutamine
- glutathione
- ITGB1
- TLN1
- MMP9
- IL6
role in cell
- growth
- apoptosis
- cell death
- expression in
- accumulation in
- quantity
- number
- invasion
- production in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- soluble fraction
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- cell surface
- cell borders
- intracellular space
- apical compartment
- cellular membrane
- focal adhesions
- podosomes
- membrane skeleton
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- intercellular junctions
- cell-cell contacts
- membrane ruffles
- plasma membrane extracellular face
- apical membrane
- synaptic membrane
- basolateral membrane
- nucleoplasm
- alpha granules
- neurites
- synapse
- melanosomes
- membrane rafts
- membrane processes
- microvilli
- filopodia
- exosomes
- basement membrane
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ITGB3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative chemotaxis
- regulation of bone resorption
- positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway
- positive regulation of angiogenesis
- wound healing
- positive regulation of vascular endothelial growth factor receptor signaling pathway
- negative regulation of endothelial cell apoptotic process
- platelet aggregation
- wound healing, spreading of epidermal cells
- negative regulation of lipid transport
- positive regulation of osteoblast proliferation
- apolipoprotein A-I-mediated signaling pathway
- regulation of protein localization
- cellular response to platelet-derived growth factor stimulus
- apoptotic cell clearance
- platelet-derived growth factor receptor signaling pathway
- positive regulation of substrate adhesion-dependent cell spreading
- positive regulation of T cell migration
- smooth muscle cell migration
- regulation of actin cytoskeleton organization
- blood coagulation, fibrin clot formation
- positive regulation of cell-matrix adhesion
- positive regulation of gene expression
- positive regulation of bone resorption
- mesodermal cell differentiation
- negative regulation of macrophage derived foam cell differentiation
- response to activity
- cell-substrate adhesion
- regulation of serotonin uptake
- viral entry into host cell
- cell adhesion
- blood coagulation
- positive regulation of smooth muscle cell proliferation
- integrin-mediated signaling pathway
- positive regulation of fibroblast proliferation
- substrate adhesion-dependent cell spreading
- activation of protein kinase activity
- positive regulation of cell adhesion mediated by integrin
- positive regulation of glomerular mesangial cell proliferation
- positive regulation of smooth muscle cell migration
- platelet activation
- positive regulation of endothelial cell migration
- cell migration
- positive regulation of peptidyl-tyrosine phosphorylation
- angiogenesis involved in wound healing
- cell-matrix adhesion
- cell-substrate junction assembly
- tube development
- embryo implantation
- regulation of release of sequestered calcium ion into cytosol
- cell adhesion mediated by integrin
- cellular response to mechanical stimulus
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein phosphorylation
- negative regulation of lipoprotein metabolic process
- negative regulation of lipid storage
- cellular response to xenobiotic stimulus
- heterotypic cell-cell adhesion
- positive regulation of endothelial cell proliferation
- positive regulation of fibroblast migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- external side of plasma membrane
- synapse
- integrin complex
- nucleoplasm
- extracellular vesicular exosome
- focal adhesion
- alphaIIb-beta3 integrin complex
- postsynaptic membrane
- alpha9-beta1 integrin-ADAM8 complex
- ruffle membrane
- lamellipodium membrane
- platelet alpha granule membrane
- alphav-beta3 integrin complex
- receptor complex
- plasma membrane
- cell surface
- filopodium membrane
- nucleus
- microvillus membrane
- alphav-beta3 integrin-vitronectin complex
- cell-cell junction
- melanosome
- alphav-beta3 integrin-PKCalpha complex
- alphav-beta3 integrin-IGF-1-IGF1R complex
- macromolecular complex
- alphav-beta3 integrin-HMGB1 complex
- apical plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein kinase C binding
- coreceptor activity
- identical protein binding
- platelet-derived growth factor receptor binding
- neuregulin binding
- cell adhesion molecule binding
- integrin binding
- protease binding
- extracellular matrix binding
- fibrinogen binding
- protein disulfide isomerase activity
- protein binding
- vascular endothelial growth factor receptor 2 binding
- metal ion binding
- fibronectin binding
- C-X3-C chemokine binding
- fibroblast growth factor binding
- viral receptor activity
- insulin-like growth factor I binding
- enzyme binding