CCL15

CCL15 Gene Summary

This gene is located in a cluster of similar genes in the same region of chromosome 17. These genes encode CC cytokines, which are secreted proteins characterized by two adjacent cysteines. The product of this gene is chemotactic for T cells and monocytes, and acts through C-C chemokine receptor type 1 (CCR1). The proprotein is further processed into numerous smaller functional peptides. Naturally-occurring readthrough transcripts occur from this gene into the downstream gene, CCL14 (chemokine (C-C motif) ligand 14). [provided by RefSeq, Jan 2013]

Details

Type
Protein Coding
Official Symbol
CCL15
Official Name
C-C motif chemokine ligand 15 [Source:HGNC Symbol;Acc:HGNC:10613]
Ensembl ID
ENSG00000275528
Bio databases IDs NCBI: 6359 Ensembl: ENSG00000275528
Aliases C-C motif chemokine ligand 15
Synonyms
C-C motif chemokine ligand 15,HCC-2,HMRP-2B,LKN-1,MIP-1D,MIP-1delta,MIP-5,MRP-2B,NCC-3,SCYA15,SCYL3,SY15
Species
Human, homo_sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • chemokine
  • chemoattractant
  • Small cytokines (intecrine/chemokine), interleukin-8 like
  • receptor binding
  • cytokine

Pathways

Biological processes and signaling networks where the CCL15 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • CCR1
  • MLYCD
  • TLNRD1
  • COL6A1
  • HNF4A
  • CCR3
  • WDR45B
  • BLK
  • CCL2
disease
  • organismal death
  • preeclampsia
  • endometriosis
  • renal clear cell adenocarcinoma
  • renal clear cell cancer
  • colon cancer
  • pancreatic ductal adenocarcinoma
  • pancreatic epithelial cancer
  • ductal pancreatic cancer
  • uterine serous papillary cancer
regulated by
  • HUVEC cells
  • lipopolysaccharide
  • TNF
  • CD14+ cells
  • MMP9
  • Caco2 cells
  • MMP25
  • neutrophils
  • NR1H4
  • MMP8
regulates
  • ICAM1
  • cyclic AMP
  • p38 MAPK
  • Ca2+
  • STAT3
  • CXCL8
  • NFkB (complex)
  • IL6
  • CREB3
  • cytokine
role in cell
  • expression in
  • phosphorylation in
  • accumulation in
  • adhesion
  • binding
  • migration
  • chemotaxis
  • invasion by
  • production in
  • binding in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • cell surface

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the CCL15 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • chemotaxis
  • inflammatory response
  • signal transduction
  • positive chemotaxis
  • chemokine-mediated signaling pathway
  • eosinophil chemotaxis
  • cell-cell signaling
  • positive regulation of GTPase activity
  • positive regulation of cell migration
  • cellular calcium ion homeostasis

CELLULAR COMPONENT

Where in the cell the gene product is active
  • extracellular space

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • CCR chemokine receptor binding
  • chemoattractant activity
  • heparin binding
  • chemokine activity
  • receptor binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.