Dpp8 Gene Summary [Mouse]
Predicted to enable dipeptidyl-peptidase activity. Predicted to be involved in negative regulation of programmed cell death and proteolysis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; immune system; limb mesenchyme; metanephros; and skin. Orthologous to human DPP8 (dipeptidyl peptidase 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dpp8 |
| Official Name | dipeptidylpeptidase 8 [Source:MGI Symbol;Acc:MGI:1921638] |
| Ensembl ID | ENSMUSG00000032393 |
| Bio databases IDs | |
| Aliases | dipeptidylpeptidase 8 |
| Synonyms | 2310004I03RIK, 4932434F09Rik, dipeptidyl peptidase 8, DP8, DPP VIII, DPRP-1, MST097, MSTP097, MSTP135, MSTP141 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dpp8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prolyl oligopeptidase family
- Dipeptidyl peptidase IV (DPP IV) N-terminal region
- Dipeptidyl peptidase 8 and 9 N-terminal
- alpha/beta hydrolase fold domain
- peptidase
- dipeptidyl-peptidase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- pervasive developmental disorder
- polycythemia vera
regulated by
- T lymphocytes
- hematopoietic progenitor cells
- 1G244
role in cell
- apoptosis
- proliferation
- activation in
- cell death
- survival
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dpp8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- proteolysis
- apoptotic process
- negative regulation of programmed cell death
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type peptidase activity
- aminopeptidase activity
- dipeptidyl-peptidase activity