Sun2 Gene Summary [Mouse]
Enables identical protein binding activity. Involved in centrosome localization; nuclear migration; and positive regulation of cell migration. Located in chromosome, telomeric region; condensed nuclear chromosome; and nuclear inner membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; skeletal muscle; and skin. Orthologous to human SUN2 (Sad1 and UNC84 domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Sun2 |
| Official Name | Sad1 and UNC84 domain containing 2 [Source:MGI Symbol;Acc:MGI:2443011] |
| Ensembl ID | ENSMUSG00000042524 |
| Bio databases IDs | |
| Aliases | Sad1 and UNC84 domain containing 2 |
| Synonyms | B230369L08Rik, C030011B15, FRIGG, rab5IP, RGD1563141, Sad1 and UNC84 domain containing 2, UNC84B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sun2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- coiled-coil domain 1 of SUN domain-containing proteins
- Sad1 / UNC-like C-terminal
- nuclear localization sequence
- protein binding activity, bridging
- lamin binding
- protein binding
- SUN2 helix-turn-helix domain
- identical protein binding
- Apolipoprotein A1/A4/E domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- alopecia
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- diverticular disease
- prostate cancer
- prostatic carcinoma
- ataxia
- cyanosis
role in cell
- apoptosis
- proliferation
- invasion by
- morphology
- quantity
- accumulation in
- activation in
- S phase
- migration
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear membrane fraction
- pH resistant lipid raft fraction
- Cytoplasm
- endosomes
- Endoplasmic Reticulum
- chromosome
- nuclear pores
- inner nuclear membrane
- spindle pole
- nuclear envelope
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sun2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centrosome localization
- nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration
- meiotic cell cycle
- mitotic spindle organization
- nuclear migration
- nuclear migration along microfilament
- nuclear matrix anchoring at nuclear membrane
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- chromosome, telomeric region
- nuclear inner membrane
- nuclear membrane
- endosome membrane
- SUN-KASH complex
- condensed nuclear chromosome
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein anchor
- lamin binding
- microtubule binding