Kcmf1 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of HRI-mediated signaling; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Predicted to act upstream of or within protein ubiquitination. Predicted to be located in cytosol. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including early conceptus; gonad; hemolymphoid system gland; liver; and lung. Orthologous to human KCMF1 (potassium channel modulatory factor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcmf1 |
| Official Name | potassium channel modulatory factor 1 [Source:MGI Symbol;Acc:MGI:1921537] |
| Ensembl ID | ENSMUSG00000055239 |
| Bio databases IDs | |
| Aliases | potassium channel modulatory factor 1 |
| Synonyms | 1700094M07Rik, DEBT91, FIGC, LOC100047784, PCMF, Pmcf, potassium channel modulatory factor 1, ZZZ1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcmf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ZZ
- Drought induced 19 protein (Di19), zinc-binding
- ubiquitin protein ligase activity
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- ficolin-1-rich granule lumen
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcmf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
- protein K63-linked ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- synapse
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding