Il11ra1 Gene Summary [Mouse]
Enables interleukin-11 binding activity and interleukin-11 receptor activity. Acts upstream of or within several processes, including cytokine-mediated signaling pathway; decidualization; and natural killer cell differentiation. Predicted to be located in extracellular region and membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; immune system; and nervous system. Orthologous to human IL11RA (interleukin 11 receptor subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il11ra1 |
| Official Name | interleukin 11 receptor, alpha chain 1 [Source:MGI Symbol;Acc:MGI:107426] |
| Ensembl ID | ENSMUSG00000073889 |
| Bio databases IDs | |
| Aliases | interleukin 11 receptor, alpha chain 1 |
| Synonyms | CRSDA, GP130, Il11ra1, Il11ra2, IL-11R alpha, IL-11R α, interleukin 11 receptor subunit alpha, interleukin 11 receptor subunit alpha 1, interleukin 11 receptor subunit α, interleukin 11 receptor subunit α 1, NR1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il11ra1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-11 receptor
- binding protein
- FN3
- immunoglobulin domain
- interleukin-11 binding
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Fibronectin type 3 domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Il11ra1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- obesity
- hepatic steatosis
- kidney disease
- tumorigenesis
- osteoarthritis
- thrombocytopenia
- craniosynostosis and dental anomalies
- fibrosis
- osteosarcoma
role in cell
- phosphorylation in
- formation
- proliferation
- apoptosis
- activation in
- number
- cellular infiltration by
- accumulation
- synthesis in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il11ra1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- head development
- interleukin-11-mediated signaling pathway
- cytokine-mediated signaling pathway
- positive regulation of cell proliferation
- developmental process
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- receptor complex
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- interleukin-11 receptor activity
- transmembrane signaling receptor activity
- interleukin-11 binding