Cacna1b Gene Summary [Rat]
Enables high voltage-gated calcium channel activity; protein phosphatase 2A binding activity; and voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in several processes, including calcium ion import; regulation of calcium-dependent activation of synaptic vesicle fusion; and response to phorbol 13-acetate 12-myristate. Located in axon terminus; dendritic shaft; and neuronal cell body. Part of protein-containing complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome. Orthologous to human CACNA1B (calcium voltage-gated channel subunit alpha1 B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cacna1b |
| Official Name | calcium voltage-gated channel subunit alpha1 B [Source:RGD Symbol;Acc:628852] |
| Ensembl ID | ENSRNOG00000004560 |
| Bio databases IDs | |
| Aliases | calcium voltage-gated channel subunit alpha1 B |
| Synonyms | alpha(1B), BIII, CACNL1A5, CACNN, calcium channel, voltage-dependent, N type, alpha 1B subunit, calcium channel, voltage-dependent, N type, α 1B subunit, calcium voltage-gated channel subunit alpha1 B, Cav2.2, Cchn1a, DYT23, LOC101060829, LOC102553311, NEDNEH, N-type CALCIUM CHANNEL alpha1B, Vdcc α 1b, α(1B) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cacna1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Voltage-dependent L-type calcium channel, IQ-associated
- synprint domain
- Ion transport protein
- high voltage-gated calcium channel
- protein phosphatase binding
- protein binding
- ion channel
- voltage-gated calcium channel
- Voltage gated calcium channel IQ domain
- ankyrin binding domain
- PDZ binding motif
- Polycystin cation channel
- DII/III loop domain
Pathways
Biological processes and signaling networks where the Cacna1b gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Androgen Signaling
- Calcium Signaling
- Cardiac β-adrenergic Signaling
- CCR5 Signaling in Macrophages
- Cellular Effects of Sildenafil (Viagra)
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- FcγRIIB Signaling in B Lymphocytes
- G Beta Gamma Signaling
- GABA Receptor Signaling
- GNRH Signaling
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- Gustation Pathway
- Huntington's Disease Signaling
- Maturity Onset Diabetes of Young (MODY) Signaling
- Netrin Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- nNOS Signaling in Skeletal Muscle Cells
- Role of NFAT in Cardiac Hypertrophy
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- pain
- postoperative pain
- dementia
- chronic pain
- rotator cuff tear
- morbid obesity
- acute pain
- mucositis
- postoperative nausea and vomiting
role in cell
- expression in
- quantity
- migration
- phosphorylation in
- formation
- invasion by
- transmission
- formation in
- neurotransmission
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- cell surface
- apical compartment
- cellular membrane
- flagella
- basolateral membrane
- sperm head
- neuromuscular junctions
- neurites
- nerve ending
- synaptosomes
- synapse
- perikaryon
- axons
- dendrites
- axon terminals
- presynaptic terminals
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cacna1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synaptic transmission
- synaptic transmission
Cellular Component
Where in the cell the gene product is active
- voltage-gated calcium channel complex
- synapse
- neuronal cell body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- high voltage-gated calcium channel activity
- calcium ion binding
- voltage-gated calcium channel activity
- beta-amyloid binding