Mmp16 Gene Summary [Rat]
Predicted to enable metalloaminopeptidase activity; metalloendopeptidase activity; and zinc ion binding activity. Involved in response to odorant. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space and plasma membrane. Orthologous to human MMP16 (matrix metallopeptidase 16). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mmp16 |
| Official Name | matrix metallopeptidase 16 [Source:RGD Symbol;Acc:620199] |
| Ensembl ID | ENSRNOG00000005708 |
| Bio databases IDs | |
| Aliases | matrix metallopeptidase 16 |
| Synonyms | C8orf57, DKFZP761D112, matrix metallopeptidase 16, MMP-X2, MT3-MMP, MT-MMP2, MT-MMP 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mmp16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hemopexin-like repeats
- Matrixin
- metalloexopeptidase
- catalytic domain
- peptidase
- HX
- Domain of unknown function (DUF3377)
- Zinc-dependent metalloprotease
- enzyme activator activity
- Putative peptidoglycan binding domain
- ZnMc
- zinc ion binding
- aminopeptidase
- transmembrane domain
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Mmp16 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Axonal Guidance Signaling
- Bladder Cancer Signaling
- Colorectal Cancer Metastasis Signaling
- Estrogen Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- HIF1α Signaling
- Inhibition of Matrix Metalloproteases
- Leukocyte Extravasation Signaling
- Molecular Mechanisms of Cancer
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- schizophrenia
- hypoplasia
- cough
- growth failure
- cleft lip
- Dupuytren contracture
- osteoarthritis
- cleft palate
- laser induced choroidal neovascularization
role in cell
- accumulation in
- proliferation
- phosphorylation in
- molecular cleavage in
- collapse
- adhesion
- abnormal morphology
- endochondral ossification by
- ossification by
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- perinuclear Golgi regions
- cell surface
- cellular membrane
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mmp16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal system development
- proteolysis
- extracellular matrix organization
- embryonic cranial skeleton morphogenesis
- endochondral ossification
- chondrocyte proliferation
- protein processing
- collagen catabolic process
- craniofacial suture morphogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular matrix
- Golgi lumen
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- metalloaminopeptidase activity
- enzyme activator activity
- metalloendopeptidase activity