Syn1 Gene Summary [Rat]
Enables calcium-dependent protein binding activity. Involved in neuron development and synapse organization. Located in dendrite; presynaptic active zone; and synaptic vesicle. Is extrinsic component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in X-linked epilepsy with variable learning disabilities and behavior disorders and non-syndromic X-linked intellectual disability 50. Orthologous to human SYN1 (synapsin I). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Syn1 |
| Official Name | synapsin I [Source:RGD Symbol;Acc:3797] |
| Ensembl ID | ENSRNOG00000010365 |
| Bio databases IDs | |
| Aliases | synapsin I |
| Synonyms | EPILX, EPILX1, MRX50, SYN1a, SYN1b, Syn1-S, Synapsin-1, Synapsin I, Synapsin Ia, Synapsin Ib, SYNI |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Syn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- protein kinase binding
- camkii phosphorylation site
- protein binding activity, bridging
- ATP binding
- Synapsin N-terminal
- protein binding
- Synapsin, N-terminal domain
- identical protein binding
- proline rich domain
- cytoskeletal adaptor
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- alpha-L-glutamate ligase, RimK family
- PXXP motif
- Pka phosphorylation site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bipolar disorder
- Alzheimer disease
- treatment resistant depression
- X-linked epilepsy with variable learning disabilities and behavior disorders
- mental retardation
- Parkinson disease
- Down syndrome
- tonic-clonic seizure
- x-linked mental retardation type 50
- epilepsy
role in cell
- quantity
- growth
- formation
- size
- morphology
- organization
- recycling
- cross-linkage
- synaptic depression
- posttetanic potentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microsomal fraction
- myelin enriched fraction
- endoplasmic reticulum fraction
- postsynaptic density (PSD) fractions
- Golgi-enriched fraction
- membrane fraction
- synaptosomal membrane fractions
- synaptic vesicle membrane
- glutaminergic synapse
- cytoskeleton
- Cytoplasm
- presynaptic regions
- cellular membrane
- vacuole
- vesicles
- cytosol
- synaptic vesicles
- growth cone
- neurites
- nerve ending
- synaptosomes
- synapse
- transport vesicles
- cellular protrusions
- membrane processes
- synaptonemal complexes
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- mossy fiber boutons
- presynaptic terminals
- detergent-soluble fraction
- synaptic vesicle fractions
- synaptosomal fractions
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Syn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of neurotransmitter secretion
- synapse organization
- regulation of synaptic vesicle exocytosis
- synaptic transmission
- synaptic vesicle clustering
- neuron development
- neurotransmitter secretion
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- dendrite
- cytoskeleton
- presynaptic active zone
- synaptic vesicle
- cell body
- Golgi apparatus
- synaptic vesicle membrane
- synaptonemal complex
- axon
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ATP binding
- identical protein binding
- protein binding
- actin binding
- calcium-dependent protein binding