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Mitochondrial Dysfunction

Mitochondria are the primary consumers of oxygen in a cell and contain a multitude of redox carriers that are capable of transferring single electrons to oxygen. This results in the formation of the reactive oxygen species (ROS) superoxide. Mitochondria also contain an extensive antioxidant defense system to detoxify ROS, which would otherwise cause oxidative damage to cellular components. Thus, in structurally and functionally intact mitochondria, there is little net ROS production. Mitochondrial dysfunction occurs when the ROS-mediated oxidative stress overpowers the antioxidant defense system...

Mitochondrial Dysfunction

Pathway Summary

Mitochondria are the primary consumers of oxygen in a cell and contain a multitude of redox carriers that are capable of transferring single electrons to oxygen. This results in the formation of the reactive oxygen species (ROS) superoxide. Mitochondria also contain an extensive antioxidant defense system to detoxify ROS, which would otherwise cause oxidative damage to cellular components. Thus, in structurally and functionally intact mitochondria, there is little net ROS production. Mitochondrial dysfunction occurs when the ROS-mediated oxidative stress overpowers the antioxidant defense system. The factors for triggering oxidative stress can be genetic defects, environmental factors like radiation and toxins and metabolic fluctuations. Neurodegenerative disorders, diabetes and cardiac ischemia are disease conditions that are associated with mitochondrial dysfunction.

Mitochondrial Dysfunction Genes list

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Products related to Mitochondrial Dysfunction

Explore products related to Mitochondrial Dysfunction
GeneGlobe ID: PAHS-087Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Mitochondria
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: SBHS-008Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Mitochondrial Energy Metabolism
QuantiNova LNA PCR Focus Panel
Product Specification
GeneGlobe ID: UPHS-087Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Mitochondria
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-087Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Mitochondria
QuantiNova LNA PCR Focus Panel
Product Specification
GeneGlobe ID: UPHS-008Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Mitochondrial Energy Metabolism
QuantiNova LNA Probe PCR Focus Panel
Product Specification

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