Target List
AKT & PI3 Kinase Family Members & Their Regulators
AKT1, AKT2, AKT3, BTK, GRB10, GRB2, HSPB1 (HSP27), ILK, MTCP1, PDK2, PDPK1, PIK3CA (p110-alpha), PIK3CG, PIK3R1 (p85-ALPHA), PIK3R2 (p85-BETA), PAK1, PRKCA, PRKCB, PRKCZ, PTEN, TCL1A
IGF-1 Signaling
CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3 (ERK1), MAPK8 (JNK1), PTPN11, RAF1, RASA1, SHC1, SOS1, SRF
GSK3 Inactivation & β-Catenin Accumulation
ADAR, AKT1, APC, CCND1, CD14, CTNNB1, EIF2AK2, GJA1 (CX43), GSK3B, IRAK1, MYD88, NFKB1, PDK1, TIRAP, TLR4, TOLLIP
Cytoskeleton Regulators
CDC42, PDGFRA, RAC1, RHOA, WASL
PTEN-Dependent Cell Cycle Arrest & Apoptosis
AKT1, CDKN1B (P27KIP1), FASLG (TNFSF6), FOXO3, GRB2, ILK, ITGB1, MAPK1 (ERK2), MAPK3 (ERK1), PDK1, PDK2, PTEN, PTK2 (FAK), RBL2, SHC1, SOS1
BAD Phosphorylation & Anti-Apoptotic Pathways
AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1 (ERK2), MAPK3 (ERK1), RAF1, RPS6KA1, SHC1, SOS1, YWHAH
mTOR Signaling
AKT1, EIF4B, EIF4E, EIF4EBP1 (4E-BP1), EIF4G1, FKBP1A (FKBP12), MTOR, PDK1, PDK2, PTEN, RHEB, RPS6KB1, TSC1, TSC2
Regulation of eIF4e & p70 S6 Kinases
AKT1, EIF4E, EIF4EBP1 (4E-BP1), EIF4G1, MTOR, IRS1, MAPK1 (ERK2), MAPK14 (p38ALPHA), MAPK3 (ERK1), PABPC1, PDK1, PDK2, PRKCA, PTEN
Regulation of Adipogenesis
RPS6KB1
Other AKT Signaling Genes
CASP9, CHUK (IKKα), FOXO1, NFKBIA (IκBα, MAD3)