Target List
MAP Kinase Signaling
ARAF, BRAF, DLK1, MAP3K1 (MEKK1), MAP3K2 (MEKK2), MAP3K3 (MEKK3), MAP3K4 (MEKK4), MAP4K1 (HPK1), MOS, MST1, PAK1, RAF1, MAP2K1, MAP2K2 (MEK2), MAP2K3 (MEK3), MAP2K4 (MKK4, JNKK1), MAP2K5 (MEK5), MAP2K6 (MEK6, MKK6), MAP2K7 (JNKK2), MAPK1 (ERK2), MAPK3 (ERK1), MAPK6 (ERK3), MAPK7 (ERK7), MAPK8 (JNK1), MAPK9 (JNK2), MAPK10 (JNK3), MAPK11 (p38Beta), MAPK12 (p38GAMMA), MAPK13 (p38delta), MAPK14 (p38ALPHA)
Activated Transcription Factors
ATF2 (CREB2), CREB1, CREBBP (CBP), EGFR (ERBB1), ELK1, ETS1, ETS2, JUN, MAPKAPK2, MAPKAPK3, MAX, MEF2C, MKNK1, MYC, NFATC4 (NFAT3), PRDX6 (AOP2), SMAD4 (MADH4), TP53 (p53)
Induced by MAP Kinase Signaling
COL1A1, EGR1, FOS, HSPA5 (GRP78), HSPB1 (HSP27), JUN, MYC, TP53 (p53)
Raf Regulating Proteins
HRAS, KRAS, KSR1, MAP2K1, MAP2K2 (MEK2), NRAS
MEKK1 Interacting Proteins
CDC42, CHUK (IKKα), GRB2, HRAS, KRAS, MAP2K1, MAP2K2 (MEK2), MAP2K4 (MKK4, JNKK1), MAP2K7 (JNKK2), MAP4K1 (HPK1), MST1, NRAS, RAC1, SFN (14-3-3σ, YWHAS)
Scaffolding & Anchoring Proteins
LAMTOR3 (MP1), MAP3K1 (MEKK1), MAPK8IP2 (JIP-1)
Cell Cycle Proteins Regulated by ERK1/2 Signaling
CCNA1, CCNA2, CCNB1, CCNB2, CCND1, CCND2, CCND3, CCNE1, CDK2, CDK4, CDK6, CDKN1A (p21CIP1, WAF1), CDKN1B (P27KIP1), CDKN1C (p57Kip2), CDKN2A (P16INK4A), CDKN2B (p15INK4b), CDKN2C (p18-INK4C), CDKN2D (p19-INK4D), E2F1, RB1