Non-Small Cell Lung Cancer Signaling
Non-small cell lung cancer (NSCLC) accounts for approximately 80% of lung cancers. It represents a heterogeneous group of cancers consisting mainly of squamous cell, adeno and large-cell carcinoma. Genetic alterations seen in NSCLC include activation of oncogenes or the inactivation of tumor suppressor genes. Mutations in the K-Ras oncogene inactivate GTPase activity, leading to a continuous transmition of growth signals to the nucleus. K-Ras mutations also affect the PI3K/AKT and Ras/Raf/ERK signaling pathways resulting in uncontrolled cell proliferation and inhibition of apoptosis...
Pathway Summary
Non-small cell lung cancer (NSCLC) accounts for approximately 80% of lung cancers. It represents a heterogeneous group of cancers consisting mainly of squamous cell, adeno and large-cell carcinoma. Genetic alterations seen in NSCLC include activation of oncogenes or the inactivation of tumor suppressor genes. Mutations in the K-Ras oncogene inactivate GTPase activity, leading to a continuous transmition of growth signals to the nucleus. K-Ras mutations also affect the PI3K/AKT and Ras/Raf/ERK signaling pathways resulting in uncontrolled cell proliferation and inhibition of apoptosis.Tumor suppressor genes that are inactivated include p53, RASSF1, p16INK4a, FHIT and retinoic acid receptor (RAR)-β. Loss of p16INK4a interferes with the cell cycle while inactivation of p53 results in rapid cellular proliferation and reduced apoptotic signals. RASSF1A forms heterodimers with Nore-1, a RAS effector. Loss of RASSF1A shifts RAS signaling towards growth promoting activity.Retinoic acid plays an important role in lung development and differentiation, acting primarily via the RAR-β gene. Promoter methylation and silencing of the RAR-β gene is frequently seen in SCLC. Overexpression of c-erbB-2 or EGFR leads to a proliferative advantage via the PI3K/AKT and Ras/Raf/ERK signaling pathways.
Non-Small Cell Lung Cancer Signaling Genes list
Explore Genes related to Non-Small Cell Lung Cancer Signaling
ABL1ABL proto-oncogene 1, non-receptor tyrosine kinase AKT1AKT serine/threonine kinase 1 AKT2AKT serine/threonine kinase 2 AKT3AKT serine/threonine kinase 3 BADBCL2 associated agonist of cell death CASP9caspase 9 CCND1cyclin D1 CCND2cyclin D2 CCND3cyclin D3 CDK4cyclin dependent kinase 4 CDK6cyclin dependent kinase 6 CDKN2Acyclin dependent kinase inhibitor 2A E2F1E2F transcription factor 1 E2F2E2F transcription factor 2 E2F3E2F transcription factor 3 E2F4E2F transcription factor 4 E2F5E2F transcription factor 5 E2F6E2F transcription factor 6 EGFepidermal growth factor EGFRepidermal growth factor receptor ERASES cell expressed Ras ERBB2erb-b2 receptor tyrosine kinase 2 FHITfragile histidine triad diadenosine triphosphatase FOXO3forkhead box O3 GRB2growth factor receptor bound protein 2 HDAC1histone deacetylase 1 HDAC10histone deacetylase 10 HDAC11histone deacetylase 11 HDAC2histone deacetylase 2 HDAC3histone deacetylase 3 HDAC4histone deacetylase 4 HDAC5histone deacetylase 5 HDAC6histone deacetylase 6 HDAC7histone deacetylase 7 HDAC8histone deacetylase 8 HDAC9histone deacetylase 9 HRASHRas proto-oncogene, GTPase KRASKRAS proto-oncogene, GTPase MAP2K1mitogen-activated protein kinase kinase 1 MAP2K2mitogen-activated protein kinase kinase 2 MAPK1mitogen-activated protein kinase 1 MAPK14mitogen-activated protein kinase 14 MAPK3mitogen-activated protein kinase 3 MRASmuscle RAS oncogene homolog NRASNRAS proto-oncogene, GTPase PA2G4proliferation-associated 2G4 PDPK13-phosphoinositide dependent protein kinase 1 PIK3C2Aphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha PIK3C2Bphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta PIK3C2Gphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma PIK3C3phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CBphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta PIK3CGphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma PIK3R1phosphoinositide-3-kinase regulatory subunit 1 PIK3R2phosphoinositide-3-kinase regulatory subunit 2 PIK3R3phosphoinositide-3-kinase regulatory subunit 3 PIK3R4phosphoinositide-3-kinase regulatory subunit 4 PIK3R5phosphoinositide-3-kinase regulatory subunit 5 PIK3R6phosphoinositide-3-kinase regulatory subunit 6 PLCG1phospholipase C gamma 1 PRKCAprotein kinase C alpha RAF1Raf-1 proto-oncogene, serine/threonine kinase RALARAS like proto-oncogene A RALBRAS like proto-oncogene B RAP1ARAP1A, member of RAS oncogene family RAP1BRAP1B, member of RAS oncogene family RAP2ARAP2A, member of RAS oncogene family RAP2BRAP2B, member of RAS oncogene family RARBretinoic acid receptor beta RASD1ras related dexamethasone induced 1 RASD2RASD family member 2 RASSF1Ras association domain family member 1 RASSF5Ras association domain family member 5 RB1RB transcriptional corepressor 1 RBL1RB transcriptional corepressor like 1 RBL2RB transcriptional corepressor like 2 RRASRAS related RRAS2RAS related 2 RXRAretinoid X receptor alpha RXRBretinoid X receptor beta RXRGretinoid X receptor gamma SIN3ASIN3 transcription regulator family member A SOS1SOS Ras/Rac guanine nucleotide exchange factor 1 SOS2SOS Ras/Rho guanine nucleotide exchange factor 2 STK4serine/threonine kinase 4 SUV39H1suppressor of variegation 3-9 homolog 1 TFDP1transcription factor Dp-1 TGFAtransforming growth factor alpha TP53tumor protein p53