Support
icon_0328_cc_gen_hmr_bacteria-s

NRF2-mediated Oxidative Stress Response

Oxidative stress is caused by an imbalance between the production of reactive oxygen and the detoxification of reactive intermediates. Reactive intermediates such as peroxides and free radicals can be very damaging to many parts of cells such as proteins, lipids and DNA. Severe oxidative stress can trigger apoptosis and necrosis. Oxidative stress is involved in many diseases such as atherosclerosis, Parkinson's disease and Alzheimer's disease. Oxidative stress has also been linked to aging...

NRF2-mediated Oxidative Stress Response

Pathway Summary

Oxidative stress is caused by an imbalance between the production of reactive oxygen and the detoxification of reactive intermediates. Reactive intermediates such as peroxides and free radicals can be very damaging to many parts of cells such as proteins, lipids and DNA. Severe oxidative stress can trigger apoptosis and necrosis. Oxidative stress is involved in many diseases such as atherosclerosis, Parkinson's disease and Alzheimer's disease. Oxidative stress has also been linked to aging. The cellular defense response to oxidative stress includes induction of detoxifying enzymes and antioxidant enzymes. Nuclear factor-erythroid 2-related factor 2 (Nrf2) binds to the antioxidant response elements (ARE) within the promoter of these enzymes and activates their transcription. Inactive Nrf2 is retained in the cytoplasm by association with an actin-binding protein Keap1. Upon exposure of cells to oxidative stress, Nrf2 is phosphorylated in response to the protein kinase C, phosphatidylinositol 3-kinase and MAP kinase pathways. After phosphorylation, Nrf2 translocates to the nucleus, binds AREs and transactivates detoxifying enzymes and antioxidant enzymes, such as glutathione S-transferase, cytochrome P450, NAD(P)H quinone oxidoreductase, heme oxygenase and superoxide dismutase.

NRF2-mediated Oxidative Stress Response Genes list

Explore Genes related to NRF2-mediated Oxidative Stress Response

Products related to NRF2-mediated Oxidative Stress Response

Explore products related to NRF2-mediated Oxidative Stress Response
GeneGlobe ID: PAHS-076Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Heat Shock Proteins & Chaperones
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: PAHS-069Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Drug Metabolism: Phase I I Enzymes
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: PAHS-061Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human MAP Kinase Signaling Pathway
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: PAHS-079Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Ubiquitination (Ubiquitinylation)
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: PAHS-068Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Drug Metabolism: Phase I Enzymes
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: UPHS-069Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Drug Metabolism: Phase II Enzymes
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: UPHS-079Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Ubiquitination (Ubiquitylation) Pathway
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-076Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Heat Shock Proteins & Chaperones
QuantiNova LNA PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-079Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Ubiquitination (Ubiquitylation) Pathway
QuantiNova LNA PCR Focus Panel
Product Specification
GeneGlobe ID: UPHS-076Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Heat Shock Proteins & Chaperones
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-069Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Drug Metabolism: Phase II Enzymes
QuantiNova LNA PCR Focus Panel
Product Specification
GeneGlobe ID: UPHS-061Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human MAP Kinase Signaling Pathway
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-065Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Oxidative Stress
QuantiNova LNA PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-068Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Drug Metabolism: Phase I Enzymes
QuantiNova LNA PCR Focus Panel
Product Specification
GeneGlobe ID: UPHS-065Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Oxidative Stress
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: UPHS-068Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Drug Metabolism: Phase I Enzymes
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-061Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human MAP Kinase Signaling Pathway
QuantiNova LNA PCR Focus Panel
Product Specification

Didn't find what you're looking for?

Discover other products relevant to this gene list with our Panel Finder. Check it out.