Target List
TGFβ Superfamily Ligands
Activins
INHA, INHBA, INHBB
Bone Morphogenetic Proteins
AMH, BMP1, BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, GDF2 (BMP9), GDF3 (VGR-2), GDF5 (CDMP-1), GDF6, GDF7
Nodal
NODAL
TGFβ Family Members
TGFB1, TGFB2, TGFB3
Inhibitors & Cofactors of TGFβ Signaling
BAMBI, CHRD, DCN, FST, LEFTY1, LTBP1, LTBP2, NOG, TGFBI, TGFBRAP1, TGIF1, THBS1 (TSP-1)
TGFβ Superfamily Receptors
Activin Receptors
ACVR1 (ALK2), ACVR2A, ACVRL1 (ALK1)
Bone Morphogenetic Protein Receptors
AMHR2, BMPR1A (ALK3), BMPR1B (ALK6), BMPR2
TGFβ Receptors
TGFBR1 (ALK5), TGFBR2, TGFBR3
Transcription Factors & Regulators
DLX2, FOS, GSC, HIPK2, ID1, JUN, JUNB, MYC, RUNX1 (AML1), SMAD1 (MADH1), SMAD2 (MADH2), SMAD3 (MADH3), SMAD4 (MADH4), SMAD5 (MADH5), SMAD7, SOX4, STAT1, TGFB1I1, TSC22D1 (TGFB1I4)
SMAD Target Genes
TGFβ / Activin-Responsive
ATF4, CDKN1A (p21CIP1, WAF1), CDKN1B (P27KIP1), CDKN2B (p15INK4b), COL1A1, COL1A2, DCN, EMP1, FOS, GADD45B, GSC, HERPUD1, IFRD1, IGF1, IGFBP3, IL6, JUN, JUNB, MYC, PDGFB, SERPINE1 (PAI-1), TGFB1I1, TGFBI, TGIF1, TNFSF10 (TRAIL), TSC22D1 (TGFB1I4)
Bone Morphogenetic Protein Responsive
BGLAP, DLX2, ID1, ID2, JUNB, SOX4, STAT1
Molecules Regulating TGFβ Superfamily Signaling
BAMBI, BMPER, CDKN2B (p15INK4b), CHRD, ENG (EVI-1), FST, HIPK2, MECOM, NOG, PLAU (UPA), RUNX1 (AML1), SMURF1
Extracellular Matrix (ECM) & Cell Adhesion Molecules
Cell Adhesion Molecules
BGLAP, ENG (EVI-1), TGFB1I1, TGFBI
Extracellular Matrix (ECM) Structural Constituents
BGLAP, COL1A1, COL1A2, LTBP1, LTBP2, TGFBI
Cellular & Developmental Processes
Apoptosis
CDKN1A (p21CIP1, WAF1), CDKN1B (P27KIP1), HIPK2, IGFBP3, INHA, INHBA, STAT1, TGFB1
Embryonic Development
BMP4, INHBA, MECOM, SMAD3 (MADH3), SMURF1
Muscle Development
DCN, IGF1, SMAD3 (MADH3)
Neurogenesis
DLX2, INHA, INHBA, NOG
Reproduction
AMH, AMHR2, FST, INHA, INHBA, INHBB
Skeletal Development
BGLAP, BMP1, BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMPR2, CHRD, COL1A1, COL1A2, IGF1, INHA, INHBA, NOG