Target List
NFκB Signaling
NFκB Signaling Ligands & Receptors
CD27 (TNFRSF7), CD40 (TNFRSF5), CXCL8 (IL8), EGFR (ERBB1), F2R (PAR1), FASLG (TNFSF6), IL10, IL1A, IL1B, IL1R1, LTBR, NOD1 (CARD4), TLR1, TLR2, TLR3, TLR4, TLR6, TLR9, TNF, TNFRSF10A (TRAIL-R), TNFRSF10B (DR5), TNFRSF1A (TNFR1), TNFSF10 (TRAIL), TNFSF14
Signaling Downstream of NFκB
BIRC2 (c-IAP1), FADD, IRAK1, IRAK2, IRF1, MYD88, RIPK1, TBK1, TICAM1 (TRIF), TICAM2 (TRAM), TNFAIP3, TRADD, TRAF2, TRAF3, TRAF6
Cytoplasmic Sequestering / Releasing of NFκB
BCL3, CHUK (IKKα), IKBKB (IKKβ), IKBKE, IKBKG, NFKBIA (IκBα, MAD3), NFKBIB (TRIP9), NFKBIE
Transcription Factors
NFKB1, NFKB2, REL, RELA, RELB
NFκB Responsive Genes
Immune Response
CCL2 (MCP-1), CCL5 (RANTES), CSF1 (MCSF), CSF2 (GM-CSF), CSF3 (GCSF), CXCL8 (IL8), ICAM1, IFNA1, IFNG, LTA (TNFB), TNF
Apoptosis
AGT, BCL2A1 (BFL1), BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), BIRC3 (c-IAP2)
Other Factors Involved in NFκB Pathway
Kinases
AKT1, MAP3K1 (MEKK1), RAF1
Transcription Factors
ATF1, EGR1, ELK1, FOS, JUN, STAT1
Other NFκB Signaling Genes
BCL10, CARD11, CASP1 (ICE), CASP8 (FLICE), CFLAR (CASPER), HMOX1, MALT1, PSIP1, RHOA, TIMP1