Lat Gene Summary [Mouse]
Predicted to enable molecular condensate scaffold activity; protein kinase binding activity; and signaling receptor complex adaptor activity. Acts upstream of or within gene expression; inflammatory response; and lymphocyte homeostasis. Located in cell-cell junction and immunological synapse. Part of COP9 signalosome. Is expressed in liver and thymus primordium. Used to study IgG4-related disease. Human ortholog(s) of this gene implicated in immunodeficiency 52. Orthologous to human LAT (linker for activation of T cells). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lat |
| Official Name | linker for activation of T cells [Source:MGI Symbol;Acc:MGI:1342293] |
| Ensembl ID | ENSMUSG00000030742 |
| Bio databases IDs | |
| Aliases | linker for activation of T cells |
| Synonyms | IMD52, LAT1, linker for activation of T cells, p36-38, pp36 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lat often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- palmitoylation site
- protein kinase binding
- lipid raft association site
- protein binding activity, bridging
- protein binding
- proline rich domain
- Grb2 binding domain
- Linker for activation of T-cells
- kinase
- cytoplasmic domain
- receptor signaling complex scaffold protein
- transmembrane domain
- intracellular domain
- cytosolic tail domain
- membrane-proximal domain
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the Lat gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- CD28 Signaling in T Helper Cells
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Fc Epsilon RI Signaling
- G Protein Signaling Mediated by Tubby
- GP6 Signaling Pathway
- iCOS-iCOSL Signaling in T Helper Cells
- Natural Killer Cell Signaling
- Phagosome Formation
- PKCθ Signaling in T Lymphocytes
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of NFAT in Regulation of the Immune Response
- Systemic Lupus Erythematosus Signaling
- T Cell Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- immunodeficiency 52
- lymphoproliferative disorder
- hyperplasia
- multiple sclerosis
- essential thrombocythemia
- severe combined immunodeficiency
- autoimmune disease
- T-cell lymphoproliferative disorder
- thrombosis
- diffuse cutaneous systemic sclerosis
phenotypes
- abnormal startle reflex
- abnormal vitreous body morphology
- abnormal B cell activation
- abnormal B cell differentiation
- abnormal B cell number
- abnormal CD4-positive alpha beta T cell morphology
- abnormal CD8-positive alpha beta T cell morphology
- abnormal T cell activation
- abnormal T cell differentiation
- abnormal T cell morphology
- abnormal T cell physiology
- abnormal T cell proliferation
- abnormal T cell receptor delta chain V(D)J recombination
- abnormal T cell receptor gamma chain V-J recombination
- abnormal T cell selection
- abnormal T cell subpopulation ratio
- abnormal T-helper 2 cell morphology
- abnormal T-helper 2 physiology
- abnormal cytokine secretion
- abnormal double-negative T cell morphology
- abnormal effector T cell morphology
- abnormal gamma-delta T cell differentiation
- abnormal immune serum protein physiology
- abnormal immune system morphology
- abnormal immune system organ morphology
- abnormal immune system physiology
- abnormal immunoglobulin level
- abnormal lymph node cell ratio
- abnormal lymph node germinal center morphology
- abnormal lymph node secondary follicle morphology
- abnormal lymph organ size
- abnormal lymphocyte morphology
- abnormal lymphopoiesis
- abnormal mature gamma-delta T cell morphology
- abnormal plasma cell morphology
- abnormal platelet aggregation
- abnormal salivary gland morphology
- abnormal spleen morphology
- abnormal spleen periarteriolar lymphoid sheath morphology
- abnormal spleen white pulp morphology
- abnormal splenic cell ratio
- abnormal thrombosis
- abnormal thymocyte activation
- abnormal thymus cell ratio
- absent CD4-positive alpha beta T cells
- absent CD8-positive alpha-beta T cells
- absent T cells
- absent mature gamma-delta T cells
- albuminuria
- arrested T cell differentiation
- chronic inflammation
- decreased T cell number
- decreased T cell proliferation
- decreased body weight
- decreased double-negative T cell number
- decreased double-positive T cell number
- decreased platelet aggregation
- decreased thymocyte number
- enlarged lymph nodes
- enlarged spleen
- glomerulonephritis
- increased B cell number
- increased CD4-positive alpha beta T cell number
- increased IgE level
- increased IgG1 level
- increased IgM level
- increased T cell number
- increased T cell proliferation
- increased T-helper 2 cell number
- increased activated T cell number
- increased anti-chromatin antibody level
- increased anti-double stranded DNA antibody level
- increased anti-erythrocyte antigen antibody level
- increased anti-nuclear antigen antibody level
- increased autoantibody level
- increased blood urea nitrogen level
- increased double-negative T cell number
- increased eosinophil cell number
- increased immunoglobulin level
- increased inflammatory response
- increased interferon-gamma secretion
- increased interleukin-4 secretion
- increased mature gamma-delta T cell number
- increased memory T cell number
- increased plasma cell number
- increased spleen germinal center number
- increased spleen weight
- increased susceptibility to autoimmune hemolytic anemia
- kidney inflammation
- liver inflammation
- lung inflammation
- pancreas fibrosis
- pancreas inflammation
- phlebitis
- premature death
- renal fibrosis
- renal glomerular immunoglobulin deposits
- salivary gland inflammation
- small thymus
- spleen hyperplasia
- thymus hypoplasia
role in cell
- activation in
- expression in
- survival
- formation in
- phosphorylation in
- cell death
- chemotaxis
- proliferation
- formation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- raft fractions
- detergent-insoluble fractions
- membrane fraction
- Cytoplasm
- cell periphery
- perinuclear region
- cellular membrane
- vesicles
- Golgi Apparatus
- intercellular junctions
- immunological synapses
- cytosol
- microdomains
- gems
- membrane rafts
- detergent-soluble fraction
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lat gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lymphocyte homeostasis
- T cell activation
- adaptive immune response
- Ras protein signal transduction
- mast cell degranulation
- inflammatory response
- integrin-mediated signaling pathway
- immune response
- positive regulation of protein kinase activity
- gene expression
- calcium-mediated signaling
- regulation of T cell activation
- T cell receptor signaling pathway
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- membrane
- membrane raft
- Golgi apparatus
- signalosome
- plasma membrane
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- receptor signaling complex scaffold activity