Nlrp3 Gene Summary [Mouse]
Enables several functions, including ATP hydrolysis activity; phosphatidylinositol-4-phosphate binding activity; and signaling adaptor activity. Involved in several processes, including positive regulation of immune response; positive regulation of macromolecule biosynthetic process; and response to bacterium. Acts upstream of or within acute inflammatory response; defense response to virus; and regulation of inflammatory response. Located in interphase microtubule organizing center; mitochondrion; and nucleus. Part of NLRP3 inflammasome complex. Is active in membrane. Is expressed in central nervous system and retina. Used to study CINCA Syndrome; familial cold autoinflammatory syndrome 1; and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nlrp3 |
| Official Name | NLR family, pyrin domain containing 3 [Source:MGI Symbol;Acc:MGI:2653833] |
| Ensembl ID | ENSMUSG00000032691 |
| Bio databases IDs | |
| Aliases | NLR family, pyrin domain containing 3 |
| Synonyms | AGTAVPRL, AII, AII/AVP, AVP, C1orf7, CIAS1, CLR1.1, DFNA34, FCAS, FCAS1, FCU, KEFH, Mmig1, MWS, NALP3, NLR family pyrin domain containing 3, NLR family, pyrin domain containing 3, PYPAF1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nlrp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NLRC4 helical domain HD2
- PAAD/DAPIN/Pyrin domain
- Fish-specific NACHT associated domain
- NOD2 winged helix domain
- ADP binding
- ATP binding
- protein binding activity, bridging
- Leucine rich repeat
- transcription factor binding
- enzyme
- NACHT domain
- protease activator
- identical protein binding
- ATPase
- nucleotide-binding domain
- leucine-rich repeat
- peptidoglycan binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- protein phosphatase 1 regulatory subunit 42
- walker type A motif
- linker domain
- enzyme regulator activity
- protein binding
- sequence-specific DNA binding
- phosphatidylinositol binding
- nucleotide binding oligomerization domain
- Leucine rich repeat, ribonuclease inhibitor type
- Death Domain Superfamily of protein-protein interaction domains
Pathways
Biological processes and signaling networks where the Nlrp3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- cognitive impairment
- cancer
- epithelial neoplasia
- epithelial cancer
- hereditary disorder
- neoplasia
- neutrophilia
- periodontitis
- cryopyrin associated periodic syndrome
phenotypes
- abnormal CD4-positive alpha beta T cell number
- abnormal bone marrow cavity morphology
- abnormal bone marrow cell physiology
- abnormal chondrocyte physiology
- abnormal circulating chemokine level
- abnormal cytokine secretion
- abnormal dendritic cell physiology
- abnormal digestive system physiology
- abnormal gut flora balance
- abnormal interleukin-1 beta secretion
- abnormal lipid metabolism
- abnormal liver morphology
- abnormal long bone epiphysis morphology
- abnormal long bone hypertrophic chondrocyte zone
- abnormal lymph node morphology
- abnormal macrophage cytokine production
- abnormal macrophage physiology
- abnormal osteoclast differentiation
- abnormal response to infection
- abnormal skeleton development
- abnormal spleen red pulp morphology
- abnormal trabecular bone morphology
- adipose tissue inflammation
- anemia
- chronic inflammation
- decreased body weight
- decreased bone mass
- decreased bone mineral density
- decreased bone trabecula number
- decreased cell proliferation
- decreased chondrocyte number
- decreased circulating interleukin-1 beta level
- decreased circulating interleukin-12b level
- decreased circulating interleukin-18 level
- decreased circulating interleukin-5 level
- decreased compact bone area
- decreased compact bone thickness
- decreased energy expenditure
- decreased erythrocyte cell number
- decreased femur size
- decreased interleukin-1 beta secretion
- decreased lactate dehydrogenase level
- decreased lymphocyte cell number
- decreased survivor rate
- decreased susceptibility to endotoxin shock
- decreased susceptibility to experimental autoimmune encephalomyelitis
- decreased susceptibility to induced colitis
- decreased susceptibility to type IV hypersensitivity reaction
- decreased trabecular bone mass
- decreased trabecular bone thickness
- decreased width of hypertrophic chondrocyte zone
- dermatitis
- disorganized long bone epiphyseal plate
- enlarged liver
- enlarged lymph nodes
- enlarged spleen
- hepatic steatosis
- increased T-helper 1 cell number
- increased activated T cell number
- increased anti-double stranded DNA antibody level
- increased body fat mass
- increased bone resorption
- increased circulating interleukin-1 beta level
- increased circulating interleukin-13 level
- increased circulating interleukin-18 level
- increased circulating interleukin-3 level
- increased circulating interleukin-4 level
- increased circulating interleukin-6 level
- increased circulating interleukin-9 level
- increased circulating tumor necrosis factor level
- increased granulocyte number
- increased inflammatory response
- increased interferon-gamma secretion
- increased interleukin-1 beta secretion
- increased interleukin-17 secretion
- increased interleukin-18 secretion
- increased leukocyte cell number
- increased liver triglyceride level
- increased liver weight
- increased lymphocyte cell number
- increased monocyte cell number
- increased neutrophil cell number
- increased osteoclast cell number
- increased susceptibility to diet-induced obesity
- increased susceptibility to type IV hypersensitivity reaction
- joint inflammation
- meningitis
- no abnormal phenotype detected
- osteomyelitis
- oxidative stress
- postnatal growth retardation
- postnatal lethality complete penetrance
- reduced fertility
- slow postnatal weight gain
- thrombocytosis
role in cell
- apoptosis
- growth
- binding in
- phosphorylation in
- expression in
- autophagy by
- autophagy in
- cell death
- proliferation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular space
- cellular membrane
- Nucleus
- Mitochondria
- microtubule organizing centers
- cytosol
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nlrp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- osmosensory signaling pathway
- detection of biotic stimulus
- negative regulation of interleukin-1 beta production
- positive regulation of transcription from RNA polymerase II promoter
- pattern recognition receptor signaling pathway
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of type 2 immune response
- inflammatory response
- apoptotic process
- pyroptosis
- protein maturation
- positive regulation of T-helper 2 cell cytokine production
- signal transduction
- negative regulation of inflammatory response
- positive regulation of inflammatory response
- protein homooligomerization
- positive regulation of T-helper 2 cell differentiation
- NLRP3 inflammasome complex assembly
- defense response
- negative regulation of acute inflammatory response
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- cellular response to lipopolysaccharide
- innate immune response
- positive regulation of interleukin-1 beta production
- positive regulation of interleukin-4 production
Cellular Component
Where in the cell the gene product is active
- nucleus
- microtubule organizing center
- interphase microtubule organizing center
- cytoplasm
- mitochondrion
- membrane
- cytosol
- endoplasmic reticulum
- Golgi membrane
- extracellular region
- NLRP3 inflammasome complex
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- phosphatidylinositol-4-phosphate binding
- peptidoglycan binding
- ATP binding
- identical protein binding
- protein binding
- signaling adaptor activity
- sequence-specific DNA binding
- ADP binding
- protein binding, bridging
- binding, bridging