Target List
Covers specific sides of specific exons of the targeted genes based on the Human GRCh38 genome build.Analyzes the expression of the targeted genes.Covers specific hotspots of the targeted genes based on the Human GRCh38 genome build.
Acute Leukemia of Ambiguous Lineage
ABL1, AFF1, BCR, CT45A2, ETV6, EWSR1, GPHN, KMT2A, MLLT10, MN1, NUP214, PBX1, SET, TCF3, ZNF384
Acute Lymphoblastic Leukemia (ALL)
ABL1, ABL2 (ARG), ACTN4, AFDN, AFF1, AFF3, AFF4, AGGF1, ANLN, ASNS, ATF7IP, AUTS2, BCL9, BCR, BTBD18, CASC5, CREBBP (CBP), CSF1R, DDX3X, EBF1, ELL, ELN, EML1, EP300, EPS15, ESRRB, ETV6, EWSR1, FGFR1, FGFR1OP, FLT3, FOXO4, FOXP1, FRYL, GAS7, GPHN, HLF, HNRNPUL1, INPP5D, JAK2, KMT2A, KMT2E, LNP1, MAML2, MEF2D, MLLT1, MLLT10, MLLT3, MN1, MNX1, MYB, MYC, NCOA2, NOTCH1, NUP214, NUP98, P2RY8, PAX5, PBX1, PCM1, PDGFRB, PICALM, PML, PRDM16, RAP1GDS1, RARA, RCSD1, RUNX1 (AML1), SALL2, SET, SFPQ, SPI1, SSBP2, STIL, STMN1, TAF15, TAL1, TCF3, TCF7, TET1, USP9X, ZBTB16, ZMIZ1, ZMYM2, ZNF384, ZNF521, ATM, BRAF, CDKN2A (P16INK4A), CREBBP (CBP), CSF3R (GM-CSFR), DNM2, EGFR (ERBB1), FBXW7, GATA2, HRAS, MAP2K1, MLH1, PAX5, PDGFRA, PTEN, SMARCB1
Acute Myeloid Leukemia (AML)
ABI1, ABI2, ABL1, AFDN, AFF1, AFF4, ALK, ANLN, ARHGAP26, ARHGEF12, BCOR, BCR, CASC5, CBFA2T3, CBFB, CBL, CCDC88C, CEP170B, CHD1, CHIC2, CREBBP (CBP), DAB2IP, DDX10, DEK, DHH, ELL, EP300, EPS15, ERG, ETV6, FGFR1, FIP1L1, FLNA, FNBP1, FOXO3, FOXO4, FRYL, FUS, GAS7, GATA1, GLIS2, GPHN, HAUS1, HOXA9, HOXC11, HOXC13, HOXD13, IRF2BP2, JAK2, KAT6A, KDM5A, KIAA1524, KMT2A, LASP1, LNP1, LPP, LYN, MAML2, MECOM, MKL1, MLF1, MLLT1, MLLT10, MLLT11, MLLT3, MLLT6, MN1, MNX1, MYB, MYH11, MYO1F, NCKIPSD, NCOA2, NF1, NPM1, NSD1, NTRK3, NUMA1, NUP214, NUP98, PBX1, PCM1, PDGFRA, PDGFRB, PDS5A, PHF23, PICALM, PML, PRDM16, PRRX1, PSIP1, PTPRR, RANBP2, RARA, RBM15, RHEBL1, RPL22, RPN1, RUNX1 (AML1), RUNX1T1, SARNP, SEPT2, SEPT5, SEPT6, SEPT9, SET, SH3GL1, SORBS2, STAT5B, TAF15, TCF3, TET1, TFG, TOP1, TOP3A, TRIP11, UBA2, USP42, WHSC1L1, WTIP, ZBTB16, ZFYVE19, ZNF384, ASXL1, ATM, BCOR, BRAF, CDKN2A (P16INK4A), CHEK2 (RAD53), CREBBP (CBP), CSF3R (GM-CSFR), DAXX, DNM2, FLT3, GATA2, IDH1, IDH2, JAK1, JAK3, KIT (CD117), KMT2D, KRAS, MAP2K1, MPL, MYC, NRAS, PBRM1, PDGFRA, PPM1D, PTEN, PTPN11, RAD21, RET, RUNX1 (AML1), SMARCB1, SRSF2, U2AF1, WT1
Acute Myelomonocytic Leukemia (AMML)
FLNA, HOXD13, NUP98
B-Cell Acute Lymphoblastic Leukemia (B-ALL)
ABL1, ACTN4, AFF1, AFF3, AFF4, ATF7IP, BCR, BTBD18, EPS15, ERG, ESRRB, ETV6, EWSR1, FUS, GAS7, JAK2, KMT2A, MAPRE1, MLLT1, NUP214, P2RY8, PAX5, PBX1, PCM1, RUNX1 (AML1), SET, SSBP2, TCF3, USP9X, ZNF384, ZNF521
Blast Phase Chronic Myeloid Leukemia
ABL1, BCR, ETV6, JAK2
Chronic Eosinophilic Leukemia
ACSL6, TNIP1
Chronic Lymphocytic Leukemia (CLL)
MYC, NOTCH1, BRAF, CHEK2 (RAD53), CSF3R (GM-CSFR), MAP2K1, TERT
Chronic Myeloid Leukemia (CML)
ABL1, BCR, CCDC88C, ETV6, JAK2, MECOM, MN1, NDE1, NUP98, PCM1, PDGFRB, RUNX1 (AML1), ABL1, CDKN2A (P16INK4A), CREBBP (CBP), CSF3R (GM-CSFR), FBXW7, GATA2
Chronic Myelomonocytic Leukemia (CMML)
CREBBP (CBP), ELL, ETV6, KMT2A, MN1, CSF3R (GM-CSFR), HRAS, SRSF2
Myelodysplastic Syndromes (MDS)
ABL1, ACTN4, ALK, CASC5, CREBBP (CBP), DEK, ERG, ETV6, FRYL, FUS, HOXD13, JAK2, KMT2A, LNP1, MAML2, MECOM, MLF1, MN1, MNX1, NDE1, NPM1, NUP214, NUP98, PCM1, PDGFRB, PRDM16, PTPRR, RANBP2, RUNX1 (AML1), RUNX1T1, TOP1, CDKN2A (P16INK4A), CSF3R (GM-CSFR), ETNK1, GNAS, HRAS, RAD21, SETBP1, SRSF2, U2AF1, XPO1, ZRSR2
Myeloproliferative Neoplasms
ABL1, ACSL6, BCR, ETV6, FGFR1, FGFR1OP, FIP1L1, FLT3, HOXA9, HOXD13, JAK2, LYN, MECOM, MLF1, MN1, NPM1, NUP98, PDGFRB, PRKG2, PSIP1, RARA, RUNX1 (AML1), TNIP1, ZMYM2, ABL1, ASXL1, JAK2, JAK3, KRAS, MPL, NRAS, SETBP1, SF3B1, SH2B3, SRSF2
T-Cell Acute Lymphoblastic Leukemia (T-ALL)
ABL1, AFDN, AGGF1, ASNS, BCR, CASC5, DDX3X, ETV6, JAK2, KMT2A, KMT2E, MLLT1, MLLT10, NOTCH1, NUP214, PBX1, RUNX1 (AML1), SALL2, SET, SPI1, STIL, STMN1, TAL1, TCF3, TCF7
Other Leukemias
IKZF3, IRF2BP2, MYC, NPM1, PDCD1LG2, SETD2
Commercial Control Samples
ALK, BAIAP2L1, BRAF, CCDC6, CD74, EGFR (ERBB1), EML4, ERG, ETV6, FGFR3, KIF5B, LMNA, MET, NCOA4, NTRK1, NTRK3, PAX8, PPARG, RET, ROS1, SEPT14, SLC34A2, SLC45A3, TACC3, TFG, TMPRSS2, TPM3
General Leukemia Markers
ANPEP, CD19, CD200, CD33, CD34, CD38, CR2, FOXM1, FOXO3, HOXA9, ITGA6, KIT (CD117), MS4A1, RUNX1 (AML1)
Leukemia Subtype Marker
Acute Lymphoblastic Leukemia (ALL)
ANPEP, BTG1, CASP8AP2, CD19, CD1A, CD2, CD22, CD33, CD5, CD7, CD79A, CD8A, CR2, ETV6, HLA-DRA, HLA-DRB1, IL2RA (CD25), JUN, KIT (CD117), LMO1, LMO2, LYL1, MEIS1, MME, MS4A1, MYC, PBX1, PTPRC, RB1, VEGFA, WT1
B Cell Acute Lymphoblastic Leukemia (B-ALL)
BTG1, CD300A, CD72, CD79A, CD79B, CD86, CDKN2A (P16INK4A), CDKN2B (p15INK4b), CRLF2 (TSLPR), EBF1, ETV6, HOXA9, IKZF1, PAX5, RB1
T Cell Acute Lymphoblastic Leukemia (T-ALL)
BTK, CD27 (TNFRSF7), CD4, KCNN4, LMO1, LMO2, LYL1, MMP9, RUNX1 (AML1), SERPINI1, TAL1, THBS1 (TSP-1), TLX1, TLX3, VPREB3
Acute Myeloid Leukemia (AML)
ADGRE5 (CD97), ASS1, BAALC, BCL11B, BIRC5, CD200, CD300A, CD44, CD86, CD96, CD99, CLEC12A, ERG, FCGR2A, FLT3, HAVCR2, IL2RA (CD25), JUN, KIT (CD117), KLF4, LEF1, MECOM, MEIS1, MMP9, NPM1, PTPRC, THBS1 (TSP-1), VEGFA, WT1
Chronic Lymphocytic Leukemia (CLL)
ABCA6, AIM2, AKT1, BAX, BCL2, BIRC2 (c-IAP1), BTK, CD19, CD200, CD24, CD27 (TNFRSF7), CD5, CD79B, CXCR4, IL7, ITGA4 (CD49D), ITGAM, JUN, KCNN4, LAIR1, LEF1, MCL1, MMP9, MS4A1, ROR1, SERPINI1, SOX11, THBS1 (TSP-1), TNF, TTN, VEGFA, VPREB3, WNT3
Chronic Myeloid Leukemia (CML)
AURKA, AURKB, IL2RA (CD25), JUN, KIT (CD117), PTCH1, PTPRC
Other Leukemia Subtypes
CD72, IL2RA (CD25), SPI1
Leukemia Stem Cell & Proliferation Markers
ADGRG1, BAALC, BMI1, CD33, CD34, CD44, CD47, CD96, CD99, CLEC12A, CXCL12 (SDF1), CXCR4, ERG, FCGR2A, HAVCR2, IL2RA (CD25), IL3RA, KIT (CD117), KLF4, LAIR1, LIN28A, MYC, POU5F1 (OCT4), PTPRC, SOX2, THY1, WT1
Possible Prognostic Significance
Indicator of Clinical Outcome in Leukemia
AURKB, BAALC, BIRC5, ERG, FOXO3, GATA2, MECOM, MEIS1, RUNX1 (AML1), SPI1, WT1
Acute Lymphoblastic Leukemia (ALL)
ABCB1 (MDR1, PGY1), AKT1, ANPEP, BIRC5, CD33, CD3D, CD44, FLT3, HOXA9, IKZF1, JUN, MME, MYC, PAX5, SMYD2
B Cell Acute Lymphoblastic Leukemia (B-ALL)
ANPEP, CD33, CRLF2 (TSLPR), JUN, MS4A1
T Cell Acute Lymphoblastic Leukemia (T-ALL)
BCL11B, BMI1, LMO1, LMO2, LYL1, MYC, TAL1, TLX1, TLX3
Acute Myeloid Leukemia (AML)
ABCB1 (MDR1, PGY1), ANGPT2, BAALC, BCL2, BIRC2 (c-IAP1), BIRC5, BMI1, CCNA1, CD200, CD34, CD4, CD44, CD47, CD96, CLEC12A, CXCL12 (SDF1), CXCR4, ERG, GATA2, HAVCR2, HGF, IL2RA (CD25), IL3RA, KLF4, LEF1, MECOM, MEIS1, MN1, MYC, RUNX1 (AML1), SOX11, SOX2, SPI1, WT1, XIAP
Chronic Lymphocytic Leukemia (CLL)
ABCA6, ANGPT2, BCL2, CD24, CD38, CD69, ITGA4 (CD49D), KCNN4, LAIR1, LPL, MS4A1, MYC, NOTCH1, ROR1, SOX11, TTN, UGT2B17, VPREB3, WNT3, ZAP70
Chronic Myeloid Leukemia (CML)
AURKA, AURKB, LIN28A, MCL1, PTCH1
Chemotherapy Resistance Related
AKT1, AURKB, BAALC, BCL2, BIRC2 (c-IAP1), CD274 (PD-L1), CD274 (PD-L1), CD44, CD47, ERG, HLA-DRA, HLA-DRB1, IL3RA, MCL1, MYC, XIAP
Hypoxia & Oxidative Stress Related
ANGPT2, VEGFA
Treatment Target or Treatment Indicator
ASS1, BMI1, CASP8AP2, CD33, CD47, CD69, CD96, CDC25A, CDKN2A (P16INK4A), CDKN2B (p15INK4b), CLEC12A, CXCR4, FLT3, FOXM1, FOXO3, HAVCR2, IL3RA, ITGAM, KLF4, LMO2, MS4A1, MYC, PTCH1, SERPINI1, SMARCA4, TAL1, ZAP70
Associated with Invasiveness or Infiltration into Central Nervous System
CXCL12 (SDF1), CXCR4, ZAP70
Minimal Residual Disease
ADGRE5 (CD97), BAALC, BCL2, CD19, CD200, CD24, CD300A, CD44, CD47, CD69, CD72, CD79B, CD86, CD99, CLEC12A, HAVCR2, IL2RA (CD25), IL3RA, ITGA6, NPM1, PBX1, WT1
Mechanistic Role in Pathogenesis
BCL11B, BCL2, BMI1, ERG, FOXM1, GATA2, HOXA9, LMO2, LPL, MEIS1, NOTCH1, PAX5, SPI1, TAL1, TLX1, TLX3, TNF, VEGFA, WT1
Expression Altered due to Genetic Alterations
Acute Lymphoblastic Leukemia (ALL)
AHI1, BCL11A, BCL2, BCL9, BRD4, CCND2, CEBPA, CEBPB, CEBPD, CEBPE, CEBPG, CRLF2 (TSLPR), EPOR, ETV6, HOXA1, ID4, IGF2BP1, IL3, IRS4, LCK, LHX4, LMO1, LMO2, LYL1, MYB, MYC, NKX2-5, NOTCH1, OLIG2, TAL2, TLX1, TLX3
Acute Myeloid Leukemia (AML)
MECOM, NKX2-5, RANBP17, TCL1A, TLX3
Other Leukemia Subtypes & Other Genetic Alterations
BAALC, BCL11B, CRLF2 (TSLPR), ERG, KIT (CD117), LMO1, LPL, NPM1, TAL1, ZAP70
Chronic Neutrophilic Leukemia (CNL)
CSF3R (GM-CSFR)
Multiple Myeloma
ATM, BRAF, CDKN2A (P16INK4A), EGFR (ERBB1), FBXW7, HRAS, MYC, PTEN, SMARCB1
Myelofibrosis
CHEK2 (RAD53), IDH1, IDH2, SRSF2
Myeloid Malignancies
CBL, CBLB, DNMT3A, EZH2
Other Myeloid Neoplasms
BRAF, CDKN2A (P16INK4A), CUX1, FBXW7, HRAS, MYD88, PTEN, STAT3