Target List
PPARα Targets
Adipogenesis
ADIPOQ (ACRP30), LPL, NR1H3, UCP1
Fatty Acid Metabolism
ACADL, ACADM, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, CPT1A, CPT1B, CPT2, CYP27A1, CYP4A11, CYP7A1, EHHADH, FADS2, HMGCS2, PLTP, SCD
Lipid Transport
ADIPOQ (ACRP30), ANGPTL4, APOA1, APOA5, APOC3, LPL, NR1H3, OLR1
Insulin Signaling
CPT1A, SORBS1
PPARβ & PPAR[delta] Targets
Adipogenesis
ADIPOQ (ACRP30), ECH1, FABP4, LPL, UCP1
Fatty Acid Metabolism
ACAA2, ACADL, ACADM, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, CPT1A, CPT1B, CPT2, CYP4A11, CYP27A1, CYP7A1, EHHADH, ETFDH, FABP1, FABP3, FABP4, FADS2, GK, HMGCS2, MLYCD, PLTP, SCD, SLC27A1, SLC27A4
Lipid Transport
ADIPOQ (ACRP30), ANGPTL4, LPL, OLR1
Cell Proliferation
HIF1A, ILK, KLF10, PTEN
Insulin Signaling
CPT1A, PDPK1, SORBS1
Other PPARβ & PPAR[delta] Target Genes
PDPK1
PPARγ Targets
Adipogenesis
ADIPOQ (ACRP30), LPL, NR1H3, UCP1
Fatty Acid Metabolism
ACADL, ACADM, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, CPT1A, CPT1B, CPT2, CYP27A1, CYP4A11, CYP7A1, EHHADH, FADS2, GK, SCD
Lipid Transport
ADIPOQ (ACRP30), ANGPTL4, APOE, DGAT1, LPL, NR1H3, OLR1
Cell Proliferation
CLU, ELN, TXNIP
Insulin Signaling
CPT1A, DGAT1, PCK1, SORBS1
Other PPARγ Target Genes
MMP9, PCK1, PCK2
PPAR Cofactors
CHD9, CREB1, CREBBP (CBP), EP300, FGR, LPIN1, MED1, NCOA3, NCOA6, PPARGC1A (PGC-1α), PPARGC1B (PGC-1β), PPRC1, HELZ2, SIRT1, SMARCD3, SRC, TGS1
PPAR Ligand Transport
CD36, FABP1, FABP2, FABP3, FABP4, FABP5, FABP6, FABP7, SLC22A5, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6
PPAR Transcription Factors
PPARA, PPARD, PPARG, RXRA, RXRB, RXRG