Target List
G1 Phase & G1/S Transition
ANAPC2, CCND1, CCNE1, CDC25A, CDC34, CDK4, CDK6, CDKN1B (P27KIP1), CDKN3, CUL1, CUL2, CUL3, E2F1, SKP2
S Phase & DNA Replication
ABL1, CDC6, MCM2, MCM3, MCM4, MCM5, WEE1
G2 Phase & G2/M Transition
ANAPC2, BCCIP, BIRC5, CCNA2, CCNB1, CCNG1, CCNH, CCNT1, CDC25A, CDK5R1, CDK5RAP1, CDK7, CDKN3, CKS1B, CKS2, GTSE1, KPNA2, MNAT1, SERTAD1
M Phase
AURKB, CCNB2, CCNF, CDC25C, CDC6, CDK1, CDC16, CDC20, MRE11, RAD51, STMN1
Cell Cycle Checkpoint & Cell Cycle Arrest
ATM, ATR, BRCA1, BRCA2, CASP3, CCNA2, CCNG2, CDC25A, CDC25C, CDC34, CDK1, CDK2, CDKN1A (p21CIP1, WAF1), CDKN1B (P27KIP1), CDKN2A (P16INK4A), CDKN2B (p15INK4b), CDKN3, CHEK1, CHEK2 (RAD53), CUL1, CUL2, CUL3, GADD45A, HUS1, KNTC1, MAD2L1, MAD2L2, MDM2, NBN, RAD1, RAD17, RAD9A, RB1, RBBP8, TP53 (p53), WEE1
Regulation of the Cell Cycle
ABL1, ANAPC2, ATR, AURKA, BCCIP, BCL2, BRCA2, CCNB1, CCNB2, CCNC, CCND1, CCND2, CCND3, CCNE1, CCNF, CCNH, CCNT1, CDC16, CDC20, CDC25C, CDC6, CDK1, CDK2, CDK4, CDK5R1, CDK6, CDK7, CDK8, CDKN1A (p21CIP1, WAF1), CDKN1B (P27KIP1), CKS1B, E2F1, E2F4, GADD45A, KNTC1, MKI67, RAD9A, RB1, SKP2, TFDP1, TFDP2, WEE1
Negative Regulation of the Cell Cycle
ATM, BRCA1, CASP3, CDKN2B (p15INK4b), RBL1, RBL2, TP53 (p53)