NDUFAB1 Gene Summary [Human]
Predicted to enable acyl binding activity; acyl carrier activity; and fatty acid binding activity. Involved in mitochondrial respiratory chain complex I assembly and protein lipoylation. Located in mitochondrion and nucleoplasm. Part of mitochondrial respiratory chain complex I. Colocalizes with mitochondrial large ribosomal subunit. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NDUFAB1 |
| Official Name | NADH:ubiquinone oxidoreductase subunit AB1 [Source:HGNC Symbol;Acc:HGNC:7694] |
| Ensembl ID | ENSG00000004779 |
| Bio databases IDs | |
| Aliases | NADH:ubiquinone oxidoreductase subunit AB1, acyl carrier protein, mitochondrial, complex I SDAP subunit |
| Synonyms | 2210401F17Rik, 2310039H15Rik, 2610003B19Rik, 9130423F15Rik, ACP, ACP1, CI-SDAP, FASN2A, mtACP, NADH:ubiquinone oxidoreductase subunit AB1, SDAP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NDUFAB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phosphopantetheine attachment site
- fatty acid binding
- ribosome binding
- enzyme
- protein binding
- structural molecule
- ribosomal large subunit binding
Pathways
Biological processes and signaling networks where the NDUFAB1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- insulin resistance
- lung adenocarcinoma formation
- adult acute myeloid leukemia
- lung squamous cell carcinoma
- squamous cell lung cancer
- lung adenocarcinoma
- Alzheimer disease
- Huntington disease
- chronic obstructive pulmonary disease
role in cell
- growth
- development
- development in
- cell death
- transmembrane potential
- lipoylation in
- damage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial membrane
- mitochondrial matrix
- mitochondrial inner membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NDUFAB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- [2Fe-2S] cluster assembly
- mitochondrial electron transport, NADH to ubiquinone
- mitochondrial respiratory chain complex I assembly
- fatty acid biosynthetic process
- aerobic respiration
- mitochondrial ATP synthesis coupled proton transport
- iron-sulfur cluster assembly
- protein lipoylation
Cellular Component
Where in the cell the gene product is active
- respiratory chain complex I
- mitochondrial membrane
- mitochondrial matrix
- mitochondrion
- mitochondrial inner membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- fatty acid binding
- protein binding
- calcium ion binding
- acyl carrier activity
- acyl binding