P2RX4 Gene Summary [Human]
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
Details
| Type | Protein Coding |
| Official Symbol | P2RX4 |
| Official Name | purinergic receptor P2X 4 [Source:HGNC Symbol;Acc:HGNC:8535] |
| Ensembl ID | ENSG00000135124 |
| Bio databases IDs | |
| Aliases | purinergic receptor P2X 4 |
| Synonyms | D5Ertd444e, P2X4, P2X4R, purinergic receptor P2X 4, purinergic receptor P2X, ligand-gated ion channel 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human P2RX4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATP P2X receptor
- calcium channel
- channel/pore class transporter
- ATP binding
- protein binding
- receptor binding
- identical protein binding
- ion channel
- copper ion binding
- zinc ion binding
- purinergic nucleotide receptor
- ligand-gated ion channel
- ATP-gated cation channel
- cadherin binding
- cation channel
Pathways
Biological processes and signaling networks where the P2RX4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dextran sodium sulfate-induced colitis
- androgenic alopecia
- neoplasia
- metastasis
- breast cancer
- metabolic syndrome X
- passive cutaneous anaphylaxis
- memory deficits
- allodynia
- pulmonary fibrosis
role in cell
- expression in
- activation in
- signaling in
- activation
- apoptosis
- migration
- degranulation in
- depolarization
- influx in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- cell junction
- cell surface
- intracellular space
- apical compartment
- perinuclear region
- cellular membrane
- endoplasmic reticulum membrane
- synaptic membrane
- lysosome membrane
- dendritic spines
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- excitatory synapses
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human P2RX4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endothelial cell activation
- positive regulation of nitric oxide biosynthetic process
- positive regulation of calcium ion transport
- apoptotic signaling pathway
- response to axon injury
- positive regulation of calcium-mediated signaling
- positive regulation of prostaglandin secretion
- cellular response to zinc ion
- response to ischemia
- negative regulation of cardiac muscle hypertrophy
- behavioral response to pain
- calcium ion transmembrane transport
- positive regulation of endothelial cell chemotaxis
- calcium-mediated signaling
- cellular response to ATP
- sensory perception of touch
- response to fluid shear stress
- regulation of action potential in neuron
- regulation of excitatory postsynaptic membrane potential
- purinergic nucleotide receptor signaling pathway
- response to ATP
- signal transduction
- ion transmembrane transport
- regulation of ruffle assembly
- regulation of blood pressure
- positive regulation of blood vessel endothelial cell migration
- tissue homeostasis
- regulation of sodium ion transport
- sensory perception of pain
- positive regulation of calcium ion transport into cytosol
- regulation of chemotaxis
- membrane depolarization
- regulation of cardiac muscle contraction
- positive regulation of protein kinase B signaling cascade
- relaxation of cardiac muscle
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- terminal button
- dendritic spine
- cell body
- membrane
- cell junction
- neuronal cell body
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- extracellular ATP-gated cation channel activity
- ATP binding
- zinc ion binding
- identical protein binding
- protein binding
- copper ion binding
- cadherin binding
- purinergic nucleotide receptor activity
- receptor binding