IL3 Gene Summary [Human]
The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IL3 |
| Official Name | interleukin 3 [Source:HGNC Symbol;Acc:HGNC:6011] |
| Ensembl ID | ENSG00000164399 |
| Bio databases IDs | |
| Aliases | interleukin 3, multilineage-colony-stimulating factor, hematopoietic growth factor, P-cell stimulating factor, mast-cell growth factor, colony-stimulating factor, multiple |
| Synonyms | BPA, Csfmu, ERYTHROID COLONY POTENTIATING FACTOR, HCGF, interleukin 3, MCGF, MULTI-CSF, PSF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-3 receptor binding
- Interleukin-3
- protein binding
- cytokine
- growth factor
Pathways
Biological processes and signaling networks where the IL3 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Airway Inflammation in Asthma
- Communication between Innate and Adaptive Immune Cells
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F
- Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F
- Erythropoietin Signaling
- Fc Epsilon RI Signaling
- Glucocorticoid Receptor Signaling
- Hematopoiesis from Multipotent Stem Cells
- Hematopoiesis from Pluripotent Stem Cells
- Hepatic Cholestasis
- HMGB1 Signaling
- IL-17 Signaling
- IL-3 Signaling
- MSP-RON Signaling Pathway
- RAR Activation
- Role of Cytokines in Mediating Communication between Immune Cells
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Th1 and Th2 Activation Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- contact dermatitis
- epithelial cancer
- plasma cell myeloma
- collagen-induced arthritis
- cancer
- delayed hypersensitive reaction
- anemia
- polycystic kidney disease
- alkalinization
role in cell
- accumulation in
- production in
- quantity
- phagocytosis by
- expression in
- apoptosis
- number
- activation in
- phosphorylation in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- embryonic hemopoiesis
- interleukin-3-mediated signaling pathway
- positive regulation of cell proliferation
- cell-cell signaling
- nervous system development
- positive regulation of tyrosine phosphorylation of STAT protein
- positive regulation of peptidyl-tyrosine phosphorylation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- cytokine activity
- interleukin-3 receptor binding