PPA1 Gene Summary [Human]
The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PPA1 |
| Official Name | inorganic pyrophosphatase 1 [Source:HGNC Symbol;Acc:HGNC:9226] |
| Ensembl ID | ENSG00000180817 |
| Bio databases IDs | |
| Aliases | inorganic pyrophosphatase 1, cytosolic inorganic pyrophosphatase, pyrophosphate phospho-hydrolase, inorganic diphosphatase 1 |
| Synonyms | 2010317E03RIK, HEL-S-66p, inorganic pyrophosphatase 1, IOPPP, IPYR, PP, PP1, Pyp, Pyrophosphatase Inorganic, pyrophosphatase (inorganic) 1, Pyrophosphatase inorganic 1, Pyrophosphate Phosphohydrolase, SID6-8061 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Inorganic pyrophosphatase
- pyrophosphatase
- enzyme
- inorganic diphosphatase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- diabetic nephropathy
- lung adenocarcinoma
- lung adenocarcinoma formation
- colorectal cancer
- colorectal adenoma
- colorectal adenoma formation
- idiopathic scoliosis
regulates
- NAD+
- AMP
- ADP-D-ribose
- pyrophosphate
role in cell
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphate-containing compound metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- inorganic diphosphatase activity