Tbx21 Gene Summary [Mouse]
Enables DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including T-helper 1 cell lineage commitment; negative regulation of T-helper 17 cell lineage commitment; and regulation of gene expression. Acts upstream of or within T cell differentiation and positive regulation of isotype switching to IgG isotypes. Located in neuronal cell body and nucleus. Is expressed in several structures, including central nervous system; colon; genitourinary system; sensory organ; and thymus. Used to study asthma. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance and immunodeficiency 88. Orthologous to human TBX21 (T-box transcription factor 21). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tbx21 |
| Official Name | T-box 21 [Source:MGI Symbol;Acc:MGI:1888984] |
| Ensembl ID | ENSMUSG00000001444 |
| Bio databases IDs | |
| Aliases | T-box 21 |
| Synonyms | IMD88, T-BET, TBLYM, T-box 21, T-box transcription factor 21, TBT1, T-PET |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tbx21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- Casein kinase i phosphorylation site
- nucleic acid binding
- transcription modulation domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- phosphorylation site
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- T-box
- double-stranded DNA binding
- DNA-binding domain of the T-box transcription factor family
- T-box domain
Pathways
Biological processes and signaling networks where the Tbx21 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- chronic lymphocytic leukemia
- septic shock
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- immunodeficiency 88
- asthma
- acute myeloid leukemia
- atopic dermatitis
role in cell
- differentiation
- binding in
- quantity
- survival
- migration
- production in
- expression in
- repression in
- cell death
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cell surface
- intracellular space
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tbx21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of isotype switching to IgG isotypes
- T-helper 1 cell lineage commitment
- positive regulation of transcription from RNA polymerase II promoter
- response to virus
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- regulation of T cell differentiation
- negative regulation of T-helper 17 cell lineage commitment
- proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of interleukin-2 production
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- negative regulation of T-helper 17 cell differentiation
- positive regulation of T-helper 1 cell cytokine production
- lymphocyte migration
- cell fate specification
- negative regulation of T-helper 2 cell cytokine production
Cellular Component
Where in the cell the gene product is active
- nucleus
- neuronal cell body
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity