Tnfrsf10b Gene Summary [Mouse]
Predicted to enable TRAIL receptor activity; identical protein binding activity; and protease binding activity. Predicted to be involved in TRAIL-activated apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and positive regulation of apoptotic process. Predicted to act upstream of or within apoptotic process and regulation of apoptotic process. Predicted to be located in Golgi apparatus; cytosol; and membrane raft. Predicted to be active in cell surface and plasma membrane. Is expressed in bladder; liver; renal vasculature; urethra of female; and urethra of male. Human ortholog(s) of this gene implicated in carcinoma (multiple); cervical cancer; hematologic cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including TNFRSF10A (TNF receptor superfamily member 10a) and TNFRSF10B (TNF receptor superfamily member 10b). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfrsf10b |
| Official Name | tumor necrosis factor receptor superfamily, member 10b [Source:MGI Symbol;Acc:MGI:1341090] |
| Ensembl ID | ENSMUSG00000022074 |
| Bio databases IDs | |
| Aliases | tumor necrosis factor receptor superfamily, member 10b |
| Synonyms | CD262, Death receptor 5, DR, Dr4, DR5, KILLER, KILLER/DR5, Ly98, MK, TNF receptor superfamily member 10b, Tnfrsf10a, TRAIL-R, TRAIL-R2, TRAIL receptor-2, TRAIL receptor 4, TRICK2, TRICK2A, TRICK2B, TRICKB, tumor necrosis factor receptor superfamily, member 10b, tumour necrosis factor receptor superfamily, member 10b, ZTNFR9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnfrsf10b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- extracellular domain
- death receptor
- protease binding
- TNFR/NGFR cysteine-rich region
- protein binding
- identical protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- pre-ligand assembly domain
- cytoplasmic domain
- Protein of unknown function (DUF668)
- intracellular domain
- cytosolic tail domain
- membrane-proximal domain
- Death Domain Superfamily of protein-protein interaction domains
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Tnfrsf10b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- rheumatoid arthritis
- systemic lupus erythematosus
- head and neck squamous cell cancer
- head and neck cancer
- epithelial cancer
- epithelial neoplasia
- cancer
- squamous cell cancer
role in cell
- phosphorylation in
- production in
- cell death
- activation in
- expression in
- apoptosis
- survival
- differentiation
- cell viability
- blebbing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- Golgi Apparatus
- cytosol
- trans Golgi network
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnfrsf10b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- defense response to tumor cell
- cellular response to mechanical stimulus
- activation of NF-kappaB-inducing kinase activity
- apoptotic process
- positive regulation of apoptotic process
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- cell surface receptor signaling pathway
- regulation of apoptotic process
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- induction of apoptosis via death domain receptors
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity
- TRAIL binding